Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 6)

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.026, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.025, shape = 1.3
all summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 35.8, median = 29.3 mean = 32, median = 26.2 mean = 36.8, median = 30.1
all effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.92, hr = 1.12 af = 0.82, hr = 1.29 af = 0.94, hr = 1.08
HRD+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.028, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 37.9, median = 31 mean = 78.1, median = 63.8 mean = 32.9, median = 26.9
HRD+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.97, hr = 1.04 af = 2, hr = 0.41 af = 0.84, hr = 1.25
TP53+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.025, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.023, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 37.2, median = 30.4 mean = 30.2, median = 24.7 mean = 39.4, median = 32.2
TP53+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.95, hr = 1.07 af = 0.77, hr = 1.4 af = 1.01, hr = 0.99
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.028, shape = 1.3 scale = 0.021, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 72.6, median = 59.3 mean = 32.8, median = 26.8 mean = 43.2, median = 35.3
TEfus+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.86, hr = 0.45 af = 0.84, hr = 1.25 af = 1.11, hr = 0.88
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.023, shape = 1.3 scale = 0.03, shape = 1.3 scale = 0.012, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 40.6, median = 33.2 mean = 30.7, median = 25.1 mean = 78.4, median = 64
PI3K+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.04, hr = 0.95 af = 0.79, hr = 1.36 af = 2.01, hr = 0.4



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 29.4, median = 24
—- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
—+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 78.1, median = 63.8
—+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 2, hr = 0.41
–+- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 78.1, median = 63.8 mean = 29.4, median = 24 mean = 29.4, median = 24
–+- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 2, hr = 0.41 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
–++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 29.4, median = 24 mean = 78.1, median = 63.8
–++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 0.75, hr = 1.44 af = 2, hr = 0.41
-+– param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 29.4, median = 24
-+– effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
-+-+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 78.1, median = 63.8
-+-+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 2, hr = 0.41
-++- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 78.1, median = 63.8 mean = 29.4, median = 24 mean = 29.4, median = 24
-++- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 2, hr = 0.41 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
-+++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 29.4, median = 24 mean = 79.9, median = 65.3
-+++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 0.75, hr = 1.44 af = 2.05, hr = 0.39
+— param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 29.4, median = 24
+— effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 0.75, hr = 1.44
+–+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
+–+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 2, hr = 0.41
+-+- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 29.4, median = 24
+-+- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 0.75, hr = 1.44
+-++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
+-++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 2, hr = 0.41
++– param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 29.4, median = 24
++– effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 0.75, hr = 1.44
++-+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
++-+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 2, hr = 0.41
+++- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 29.4, median = 24
+++- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 0.75, hr = 1.44
++++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
++++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 2, hr = 0.41

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 5 17 6 11
HRD+ 0 4 120 0
TP53+ 1 11 1 29
TEfus+ 0 326 0 6
PI3K+ 0 7 0 416
TC1 TC2 TC3 TC4
all 0.010 0.034 0.012 0.022
HRD+ 0.000 0.008 0.240 0.000
TP53+ 0.002 0.022 0.002 0.058
TEfus+ 0.000 0.652 0.000 0.012
PI3K+ 0.000 0.014 0.000 0.832
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 25 1 2 0
HRD+ 19 0 0 11
TP53+ 175 7 140 2
TEfus+ 304 0 51 3
PI3K+ 206 5 101 0
TC1 TC2 TC3 TC4
all 0.050 0.002 0.004 0.000
HRD+ 0.038 0.000 0.000 0.022
TP53+ 0.350 0.014 0.280 0.004
TEfus+ 0.608 0.000 0.102 0.006
PI3K+ 0.412 0.010 0.202 0.000
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.086 0.012 0.046 0.014 0.020
Error subgroup 0.168 0.012 0.072 0.014 0.084
Power signature 0.952 0.000 0.652 0.240 0.832
Power subgroup 0.956 0.000 0.698 0.254 0.852

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 5 17 6 11
all futility 0 25 1 2 0
all max_n 0 0 0 0 0
all n 586 (559, 611) 278 (218, 349) 316 (255, 386) 325 (240, 400) 285 (245, 355)
all n_unique 586 (559, 611) 278 (218, 349) 316 (255, 386) 325 (240, 400) 285 (245, 355)
all time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60)
all time_stop NA (NA, NA) 42 (11, 58) 12 (11, 32) 16 (13, 19) 20 (13, 48)
all post_p NA (NA, NA) 0.06 (0, 0.39) 0.73 (0.27, 0.97) 0.15 (0.01, 0.55) 0.83 (0.43, 0.98)
all rate 0.023 (0.022, 0.025) 0.027 (0.025, 0.03) 0.022 (0.02, 0.024) 0.025 (0.023, 0.028) 0.021 (0.019, 0.024)
HRD+ graduation 0 0 4 120 0
HRD+ futility 0 19 0 0 11
HRD+ max_n 0 0 0 0 0
HRD+ n 85 (73, 98) 40 (29, 52) 42 (31, 54) 47 (35, 53) 44 (35, 56)
HRD+ n_unique 85 (73, 98) 40 (29, 52) 42 (31, 54) 47 (35, 53) 44 (35, 56)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (54, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 55 (48, 60) 58 (54, 60) 55 (49, 59) 57 (54, 59)
HRD+ post_p NA (NA, NA) 0.22 (0.03, 0.64) 0.6 (0.23, 0.9) 1 (0.96, 1) 0.32 (0.04, 0.76)
HRD+ rate 0.023 (0.019, 0.027) 0.027 (0.021, 0.035) 0.021 (0.015, 0.026) 0.009 (0.006, 0.013) 0.025 (0.019, 0.032)
TP53+ graduation 0 1 11 1 29
TP53+ futility 0 175 7 140 2
TP53+ max_n 0 0 0 0 0
TP53+ n 220 (198, 239) 100 (53, 140) 122 (89, 166) 120 (58, 161) 108 (82, 146)
TP53+ n_unique 220 (198, 239) 100 (53, 140) 122 (89, 166) 120 (58, 161) 108 (82, 146)
TP53+ time_trial 60 (60, 60) 60 (29, 60) 60 (60, 60) 60 (32, 60) 60 (60, 60)
TP53+ time_stop NA (NA, NA) 36 (26, 54) 31 (25, 54) 34 (26, 51) 30 (27, 42)
TP53+ post_p NA (NA, NA) 0.16 (0.01, 0.57) 0.72 (0.29, 0.96) 0.08 (0, 0.38) 0.83 (0.43, 0.99)
TP53+ rate 0.023 (0.02, 0.025) 0.027 (0.023, 0.033) 0.021 (0.017, 0.024) 0.029 (0.024, 0.034) 0.02 (0.017, 0.023)
TEfus+ graduation 0 0 326 0 6
TEfus+ futility 0 304 0 51 3
TEfus+ max_n 0 0 0 0 0
TEfus+ n 190 (170, 209) 80 (51, 125) 86 (51, 136) 116 (67, 166) 94 (69, 133)
TEfus+ n_unique 190 (170, 209) 80 (51, 125) 86 (51, 136) 116 (67, 166) 94 (69, 133)
TEfus+ time_trial 60 (60, 60) 53 (32, 60) 50 (32, 60) 60 (60, 60) 60 (60, 60)
TEfus+ time_stop NA (NA, NA) 42 (30, 56) 40 (30, 55) 39 (29, 52) 32 (28, 45)
TEfus+ post_p NA (NA, NA) 0.01 (0, 0.17) 1 (0.97, 1) 0.03 (0, 0.27) 0.6 (0.17, 0.94)
TEfus+ rate 0.018 (0.016, 0.021) 0.027 (0.023, 0.033) 0.01 (0.008, 0.012) 0.025 (0.021, 0.029) 0.018 (0.014, 0.021)
PI3K+ graduation 0 0 7 0 416
PI3K+ futility 0 206 5 101 0
PI3K+ max_n 0 0 0 0 0
PI3K+ n 205 (185, 223) 94 (53, 138) 117 (78, 166) 126 (60, 175) 72 (51, 127)
PI3K+ n_unique 205 (185, 223) 94 (53, 138) 117 (78, 166) 126 (60, 175) 72 (51, 127)
PI3K+ time_trial 60 (60, 60) 60 (31, 60) 60 (60, 60) 60 (35, 60) 38 (29, 60)
PI3K+ time_stop NA (NA, NA) 39 (27, 55) 33 (26, 42) 35 (25, 48) 35 (29, 53)
PI3K+ post_p NA (NA, NA) 0.09 (0, 0.43) 0.8 (0.34, 0.98) 0.05 (0, 0.34) 1 (1, 1)
PI3K+ rate 0.022 (0.019, 0.024) 0.027 (0.023, 0.033) 0.019 (0.016, 0.022) 0.028 (0.023, 0.033) 0.009 (0.007, 0.012)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 5 17 6 11
—- futility 0 25 1 2 0
—- max_n 0 0 0 0 0
—- n 177 (160, 194) 91 (75, 106) 92 (78, 105) 91 (79, 107) 91 (78, 105)
—- n_unique 177 (160, 194) 91 (75, 106) 92 (78, 105) 91 (79, 107) 91 (78, 105)
—- post_p NA (NA, NA) 0.43 (0.08, 0.86) 0.22 (0.02, 0.65) 0.23 (0.02, 0.69) 0.23 (0.03, 0.67)
—- rate 0.026 (0.023, 0.029) 0.027 (0.023, 0.032) 0.03 (0.025, 0.035) 0.029 (0.025, 0.035) 0.029 (0.025, 0.034)
—+ graduation 0 5 22 6 423
—+ futility 0 213 6 103 0
—+ max_n 0 0 0 0 0
—+ n 42 (34, 50) 22 (11, 32) 26 (17, 37) 24 (13, 33) 15 (8, 25)
—+ n_unique 42 (34, 50) 22 (11, 32) 26 (17, 37) 24 (13, 33) 15 (8, 25)
—+ post_p NA (NA, NA) 0.41 (0.13, 0.79) 0.3 (0.05, 0.73) 0.29 (0.07, 0.68) 0.98 (0.87, 1)
—+ rate 0.026 (0.02, 0.034) 0.027 (0.019, 0.038) 0.029 (0.021, 0.041) 0.03 (0.021, 0.04) 0.009 (0.004, 0.015)
–+- graduation 0 5 341 6 17
–+- futility 0 312 1 53 3
–+- max_n 0 0 0 0 0
–+- n 13 (8, 19) 6 (3, 10) 6 (2, 10) 7 (4, 12) 8 (4, 13)
–+- n_unique 13 (8, 19) 6 (3, 10) 6 (2, 10) 7 (4, 12) 8 (4, 13)
–+- post_p NA (NA, NA) 0.37 (0.14, 0.68) 0.73 (0.49, 0.93) 0.35 (0.11, 0.62) 0.35 (0.1, 0.64)
–+- rate 0.018 (0.009, 0.031) 0.029 (0.012, 0.057) 0.009 (0, 0.023) 0.03 (0.016, 0.057) 0.03 (0.015, 0.053)
–++ graduation 0 5 344 6 424
–++ futility 0 376 3 135 2
–++ max_n 0 0 0 0 0
–++ n 61 (49, 72) 25 (14, 45) 27 (16, 47) 40 (18, 64) 21 (13, 41)
–++ n_unique 61 (49, 72) 25 (14, 45) 27 (16, 47) 40 (18, 64) 21 (13, 41)
–++ post_p NA (NA, NA) 0.11 (0.01, 0.44) 0.93 (0.66, 0.99) 0.04 (0, 0.29) 0.96 (0.79, 1)
–++ rate 0.018 (0.014, 0.023) 0.027 (0.02, 0.038) 0.01 (0.006, 0.015) 0.03 (0.022, 0.039) 0.009 (0.005, 0.013)
-+– graduation 0 6 27 6 38
-+– futility 0 182 8 142 2
-+– max_n 0 0 0 0 0
-+– n 76 (65, 87) 36 (18, 48) 42 (30, 56) 37 (20, 49) 41 (29, 54)
-+– n_unique 76 (65, 87) 36 (18, 48) 42 (30, 56) 37 (20, 49) 41 (29, 54)
-+– post_p NA (NA, NA) 0.47 (0.14, 0.85) 0.35 (0.05, 0.78) 0.35 (0.07, 0.74) 0.33 (0.05, 0.74)
-+– rate 0.026 (0.021, 0.031) 0.028 (0.02, 0.036) 0.029 (0.023, 0.038) 0.03 (0.023, 0.038) 0.03 (0.023, 0.038)
-+-+ graduation 0 5 32 6 426
-+-+ futility 0 274 13 174 2
-+-+ max_n 0 0 0 0 0
-+-+ n 52 (42, 61) 24 (11, 38) 34 (20, 51) 28 (13, 41) 18 (10, 31)
-+-+ n_unique 52 (42, 61) 24 (11, 38) 34 (20, 51) 28 (13, 41) 18 (10, 31)
-+-+ post_p NA (NA, NA) 0.4 (0.1, 0.84) 0.3 (0.04, 0.74) 0.31 (0.05, 0.73) 0.99 (0.91, 1)
-+-+ rate 0.026 (0.02, 0.032) 0.028 (0.019, 0.04) 0.029 (0.021, 0.039) 0.03 (0.022, 0.041) 0.009 (0.005, 0.015)
-++- graduation 0 5 344 6 42
-++- futility 0 370 5 174 5
-++- max_n 0 0 0 0 0
-++- n 46 (37, 55) 18 (10, 31) 20 (10, 32) 25 (12, 37) 30 (17, 43)
-++- n_unique 46 (37, 55) 18 (10, 31) 20 (10, 32) 25 (12, 37) 30 (17, 43)
-++- post_p NA (NA, NA) 0.21 (0.03, 0.56) 0.94 (0.76, 1) 0.11 (0.01, 0.43) 0.1 (0.01, 0.45)
-++- rate 0.018 (0.013, 0.024) 0.028 (0.019, 0.039) 0.009 (0.004, 0.014) 0.03 (0.021, 0.041) 0.03 (0.021, 0.039)
-+++ graduation 0 5 347 6 426
-+++ futility 0 399 7 203 4
-+++ max_n 0 0 0 0 0
-+++ n 35 (25, 44) 13 (7, 28) 17 (7, 33) 21 (8, 40) 14 (7, 26)
-+++ n_unique 35 (25, 44) 13 (7, 28) 17 (7, 33) 21 (8, 40) 14 (7, 26)
-+++ post_p NA (NA, NA) 0.16 (0.03, 0.53) 0.86 (0.57, 0.98) 0.11 (0.01, 0.38) 0.9 (0.61, 0.98)
-+++ rate 0.018 (0.013, 0.024) 0.028 (0.019, 0.043) 0.01 (0.005, 0.016) 0.03 (0.021, 0.043) 0.009 (0.004, 0.016)
+— graduation 0 5 21 126 11
+— futility 0 44 1 2 11
+— max_n 0 0 0 0 0
+— n 39 (32, 48) 20 (14, 27) 21 (14, 27) 20 (14, 26) 21 (15, 27)
+— n_unique 39 (32, 48) 20 (14, 27) 21 (14, 27) 20 (14, 26) 21 (15, 27)
+— post_p NA (NA, NA) 0.41 (0.1, 0.81) 0.34 (0.08, 0.71) 0.98 (0.88, 1) 0.33 (0.06, 0.76)
+— rate 0.026 (0.02, 0.034) 0.027 (0.019, 0.039) 0.029 (0.02, 0.041) 0.009 (0.004, 0.015) 0.029 (0.021, 0.042)
+–+ graduation 0 5 26 125 416
+–+ futility 0 223 6 98 10
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.47 (0.47, 0.47) NA (NA, NA)
+–+ rate 0 (0, 0) NA (NA, NA) 0.027 (0.005, 0.112) 0 (0, 0.07) 0.025 (0.005, 0.045)
+-+- graduation 0 5 343 126 17
+-+- futility 0 324 1 53 14
+-+- max_n 0 0 0 0 0
+-+- n 28 (21, 35) 12 (6, 19) 11 (5, 19) 16 (10, 22) 17 (11, 24)
+-+- n_unique 28 (21, 35) 12 (6, 19) 11 (5, 19) 16 (10, 22) 17 (11, 24)
+-+- post_p NA (NA, NA) 0.22 (0.04, 0.57) 0.78 (0.5, 0.95) 0.85 (0.56, 0.98) 0.17 (0.02, 0.51)
+-+- rate 0.018 (0.012, 0.025) 0.027 (0.017, 0.043) 0.01 (0.003, 0.018) 0.009 (0.003, 0.017) 0.029 (0.018, 0.042)
+-++ graduation 0 5 346 125 417
+-++ futility 0 382 3 130 12
+-++ max_n 0 0 0 0 0
+-++ n 6 (4, 10) 3 (1, 6) 3 (1, 6) 4 (1, 8) 3 (0, 6)
+-++ n_unique 6 (4, 10) 3 (1, 6) 3 (1, 6) 4 (1, 8) 3 (0, 6)
+-++ post_p NA (NA, NA) 0.41 (0.24, 0.54) 0.54 (0.42, 0.67) 0.56 (0.44, 0.74) 0.55 (0.43, 0.67)
+-++ rate 0.019 (0.007, 0.041) 0.029 (0.009, 0.081) 0.008 (0, 0.031) 0.007 (0, 0.024) 0.008 (0, 0.03)
++– graduation 0 6 31 121 38
++– futility 0 196 8 132 13
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 0 (0, 2) 1 (0, 2) 0 (0, 2) 1 (0, 2)
++– n_unique 1 (0, 3) 0 (0, 2) 1 (0, 2) 0 (0, 2) 1 (0, 2)
++– post_p NA (NA, NA) 0.48 (0.43, 0.55) 0.49 (0.42, 0.57) 0.54 (0.45, 0.59) 0.49 (0.42, 0.57)
++– rate 0.026 (0, 0.081) 0.029 (0, 0.137) 0.025 (0, 0.123) 0 (0, 0.049) 0.029 (0, 0.124)
++-+ graduation 0 5 36 121 419
++-+ futility 0 282 13 162 12
++-+ max_n 0 0 0 0 0
++-+ n 9 (5, 13) 4 (1, 8) 6 (2, 10) 4 (1, 8) 3 (1, 6)
++-+ n_unique 9 (5, 13) 4 (1, 8) 6 (2, 10) 4 (1, 8) 3 (1, 6)
++-+ post_p NA (NA, NA) 0.44 (0.25, 0.65) 0.43 (0.21, 0.64) 0.65 (0.44, 0.89) 0.63 (0.45, 0.85)
++-+ rate 0.027 (0.013, 0.044) 0.027 (0.009, 0.069) 0.03 (0.011, 0.06) 0.009 (0, 0.027) 0.009 (0, 0.026)
+++- graduation 0 5 346 121 42
+++- futility 0 378 5 164 16
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) 0.55 (0.55, 0.55) 0.44 (0.44, 0.44)
+++- rate 0.014 (0, 0.242) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.018 (0.004, 0.033)
++++ graduation 0 5 349 121 419
++++ futility 0 404 7 191 14
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) 0.5 (0.49, 0.51) 0.53 (0.51, 0.55) 0.51 (0.51, 0.51) 0.54 (0.54, 0.54)
++++ rate 0 (0, 0.121) 0.037 (0, 0.109) 0 (0, 0.038) 0 (0, 0) 0 (0, 0.046)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 5 17 6 11
all time_stop 11 (10, 15) 12 (11, 33) 16 (12, 18) 20 (13, 48)
all n_trt 57 (52, 71) 64 (53, 161) 83 (62, 100) 108 (67, 238)
all n_control 110 (103, 131) 112 (93, 307) 143 (110, 168) 193 (120, 462)
all post_p 0.93 (0.91, 0.97) 0.93 (0.87, 0.99) 0.96 (0.86, 0.98) 0.98 (0.91, 1)
all order 1 (1, 1) 1 (1, 2) 1 (1, 1) 1 (1, 2)
HRD+ count 4 120
HRD+ time_stop 58 (54, 60) 55 (49, 59)
HRD+ n_trt 54 (51, 60) 51 (50, 54)
HRD+ n_control 77 (73, 84) 78 (64, 96)
HRD+ post_p 0.93 (0.89, 0.97) 1 (0.98, 1)
HRD+ order 2.5 (2, 3) 3 (2, 3)
TP53+ count 1 11 1 29
TP53+ time_stop 24 (24, 24) 38 (27, 54) 33 (33, 33) 30 (27, 43)
TP53+ n_trt 52 (52, 52) 74 (55, 98) 50 (50, 50) 55 (50, 83)
TP53+ n_control 86 (86, 86) 137 (109, 185) 122 (122, 122) 117 (91, 166)
TP53+ post_p 0.88 (0.88, 0.88) 0.97 (0.9, 0.99) 0.96 (0.96, 0.96) 0.98 (0.9, 1)
TP53+ order 1 (1, 1) 2 (1, 3) 1 (1, 1) 1 (1, 2)
TEfus+ count 326 6
TEfus+ time_stop 40 (30, 55) 31 (28, 40)
TEfus+ n_trt 70 (51, 117) 55 (52, 58)
TEfus+ n_control 128 (92, 176) 102 (88, 136)
TEfus+ post_p 0.99 (0.96, 1) 0.99 (0.92, 1)
TEfus+ order 2 (1, 2) 1 (1, 3.5)
PI3K+ count 7 416
PI3K+ time_stop 35 (27, 43) 35 (29, 53)
PI3K+ n_trt 61 (55, 85) 65 (51, 112)
PI3K+ n_control 121 (84, 144) 121 (91, 182)
PI3K+ post_p 0.98 (0.96, 0.99) 1 (0.98, 1)
PI3K+ order 2 (1, 4) 1 (1, 2)
Futility:
signature var TC1 TC2 TC3 TC4
all count 25 1 2
all time_stop 45 (14, 59) 12 (12, 12) 17 (15, 19)
all n_trt 197 (75, 244) 70 (70, 70) 81 (79, 83)
all n_control 453 (125, 575) 105 (105, 105) 148 (120, 176)
all post_p 0.01 (0, 0.04) 0.04 (0.04, 0.04) 0.02 (0.01, 0.03)
all order 3 (1, 5) 1 (1, 1) 1 (1, 1)
HRD+ count 19 11
HRD+ time_stop 55 (48, 60) 57 (54, 59)
HRD+ n_trt 50 (50, 57) 51 (50, 53)
HRD+ n_control 72 (62, 90) 84 (76, 91)
HRD+ post_p 0.04 (0.01, 0.16) 0.06 (0.01, 0.09)
HRD+ order 2 (1, 4) 3 (2, 6)
TP53+ count 175 7 140 2
TP53+ time_stop 36 (26, 55) 28 (23, 40) 34 (26, 51) 30 (28, 32)
TP53+ n_trt 67 (51, 110) 50 (50, 85) 68 (51, 111) 52 (51, 54)
TP53+ n_control 129 (91, 204) 101 (81, 144) 124 (88, 194) 112 (104, 121)
TP53+ post_p 0.09 (0.02, 0.2) 0.11 (0.05, 0.23) 0.07 (0.01, 0.18) 0.15 (0.13, 0.17)
TP53+ order 2 (1, 3) 1 (1, 2.2) 2 (1, 3) 1 (1, 1)
TEfus+ count 304 51 3
TEfus+ time_stop 42 (30, 56) 39 (29, 52) 32 (27, 45)
TEfus+ n_trt 66 (51, 105) 66 (50, 97) 54 (53, 74)
TEfus+ n_control 131 (92, 177) 127 (92, 161) 115 (101, 138)
TEfus+ post_p 0.03 (0, 0.13) 0.02 (0, 0.14) 0.07 (0.06, 0.07)
TEfus+ order 2 (1, 3) 2 (1, 4) 1 (1, 1.8)
PI3K+ count 206 5 101
PI3K+ time_stop 39 (27, 55) 30 (24, 38) 35 (25, 48)
PI3K+ n_trt 68 (51, 106) 53 (52, 65) 62 (51, 95)
PI3K+ n_control 130 (87, 188) 95 (86, 124) 116 (85, 165)
PI3K+ post_p 0.05 (0.01, 0.18) 0.17 (0.08, 0.18) 0.05 (0.01, 0.17)
PI3K+ order 2 (1, 3.5) 2 (1, 2) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC1 time 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15) 11 (10, 15)
all TC1 n 20 (17, 27) 6 (3, 7) 2 (0, 3) 8 (3, 10) 6 (3, 9) 4 (4, 6) 3 (1, 4) 3 (1, 6) 4 (3, 5) 0 (0, 0) 2 (1, 3) 1 (0, 3) 0 (0, 1) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.74 (0.58, 0.76) 0.54 (0.5, 0.67) 0.53 (0.52, 0.55) 0.52 (0.51, 0.56) 0.55 (0.51, 0.57) 0.53 (0.52, 0.55) 0.54 (0.52, 0.57) 0.53 (0.51, 0.54) 0.52 (0.51, 0.53) NA (NA, NA) 0.54 (0.53, 0.55) 0.53 (0.52, 0.53) NA (NA, NA) 0.53 (0.51, 0.54) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.008 (0.002, 0.013) 0 (0, 0) 0 (0, 0) 0 (0, 0.014) 0 (0, 0.007) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.036) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC2 count 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17
all TC2 time 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33) 12 (11, 33)
all TC2 n 23 (15, 49) 5 (2, 11) 2 (0, 6) 10 (6, 16) 9 (4, 23) 6 (3, 11) 5 (3, 13) 6 (3, 9) 4 (2, 9) 0 (0, 0) 3 (1, 7) 0 (0, 2) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.61 (0.55, 0.72) 0.54 (0.51, 0.59) 0.52 (0.5, 0.59) 0.6 (0.52, 0.85) 0.57 (0.51, 0.74) 0.53 (0.5, 0.75) 0.57 (0.52, 0.82) 0.55 (0.51, 0.78) 0.52 (0.51, 0.57) NA (NA, NA) 0.54 (0.51, 0.64) 0.52 (0.51, 0.52) NA (NA, NA) 0.51 (0.5, 0.55) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.014 (0, 0.024) 0 (0, 0.018) 0 (0, 0.013) 0 (0, 0.009) 0.012 (0, 0.021) 0 (0, 0.036) 0 (0, 0.006) 0 (0, 0.008) 0 (0, 0.021) NA (NA, NA) 0 (0, 0.004) 0 (0, 0.005) 0 (0, 0) 0 (0, 0.037) NA (NA, NA) NA (NA, NA)
all TC3 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
all TC3 time 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18) 16 (12, 18)
all TC3 n 28 (18, 32) 5 (2, 10) 2 (0, 4) 8 (5, 11) 8 (6, 20) 7 (2, 10) 6 (2, 9) 5 (3, 8) 5 (4, 6) 0 (0, 0) 4 (2, 7) 0 (0, 1) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.64 (0.54, 0.89) 0.55 (0.52, 0.58) 0.54 (0.51, 0.58) 0.53 (0.51, 0.6) 0.55 (0.52, 0.75) 0.52 (0.51, 0.54) 0.52 (0.51, 0.55) 0.54 (0.52, 0.58) 0.53 (0.52, 0.56) NA (NA, NA) 0.57 (0.53, 0.6) 0.55 (0.54, 0.56) NA (NA, NA) 0.53 (0.52, 0.54) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.011 (0.002, 0.021) 0 (0, 0.006) 0 (0, 0.043) 0.005 (0, 0.022) 0.008 (0, 0.018) 0.006 (0, 0.017) 0 (0, 0.016) 0 (0, 0) 0 (0, 0.006) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC4 count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
all TC4 time 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48) 20 (13, 48)
all TC4 n 36 (20, 63) 8 (5, 16) 2 (0, 5) 12 (7, 20) 14 (8, 25) 9 (4, 13) 6 (4, 14) 7 (2, 18) 9 (2, 12) 0 (0, 0) 4 (2, 12) 0 (0, 4) 0 (0, 1) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.63 (0.55, 0.7) 0.62 (0.51, 0.98) 0.54 (0.52, 0.55) 0.62 (0.5, 0.79) 0.62 (0.52, 0.8) 0.62 (0.54, 0.95) 0.54 (0.52, 0.7) 0.6 (0.54, 0.7) 0.57 (0.5, 0.65) NA (NA, NA) 0.55 (0.53, 0.62) 0.53 (0.51, 0.59) 0.52 (0.51, 0.53) 0.54 (0.51, 0.57) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.018 (0.009, 0.024) 0.005 (0, 0.016) 0 (0, 0.013) 0 (0, 0.01) 0.017 (0, 0.024) 0.007 (0, 0.013) 0 (0, 0.019) 0 (0, 0.015) 0 (0, 0.025) 0 (0, 0) 0 (0, 0.013) 0 (0, 0.021) 0 (0, 0) 0 (0, 0.004) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 4 4 4 4 4 4 4 4
HRD+ TC2 time 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60)
HRD+ TC2 n 24 (22, 29) 0 (0, 0) 18 (16, 21) 4 (3, 5) 0 (0, 1) 9 (3, 10) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.84 (0.81, 0.91) NA (NA, NA) 0.79 (0.73, 0.85) 0.62 (0.54, 0.63) 0.52 (0.52, 0.52) 0.62 (0.57, 0.65) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.018 (0.013, 0.021) NA (NA, NA) 0.009 (0.007, 0.011) 0.006 (0, 0.019) 0 (0, 0) 0.022 (0.006, 0.023) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 120 120 120 120 120 120 120 120
HRD+ TC3 time 55 (49, 59) 55 (49, 59) 55 (49, 59) 55 (49, 59) 55 (49, 59) 55 (49, 59) 55 (49, 59) 55 (49, 59)
HRD+ TC3 n 21 (17, 27) 0 (0, 0) 18 (14, 23) 5 (2, 9) 0 (0, 2) 5 (3, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.98 (0.81, 1) NA (NA, NA) 0.9 (0.74, 0.97) 0.58 (0.52, 0.7) 0.54 (0.52, 0.6) 0.68 (0.53, 0.91) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.009 (0.005, 0.014) 0 (0, 0.08) 0.007 (0.002, 0.013) 0 (0, 0.016) 0 (0, 0.02) 0.006 (0, 0.016) 0 (0, 0) 0 (0, 0)
TP53+ TC1 count 1 1 1 1 1 1 1 1
TP53+ TC1 time 24 (24, 24) 24 (24, 24) 24 (24, 24) 24 (24, 24) 24 (24, 24) 24 (24, 24) 24 (24, 24) 24 (24, 24)
TP53+ TC1 n 27 (27, 27) 10 (10, 10) 7 (7, 7) 5 (5, 5) 0 (0, 0) 3 (3, 3) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.8 (0.8, 0.8) 0.5 (0.5, 0.5) 0.54 (0.54, 0.54) 0.67 (0.67, 0.67) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.009 (0.009, 0.009) 0.021 (0.021, 0.021) 0.01 (0.01, 0.01) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 11 11 11 11 11 11 11 11
TP53+ TC2 time 38 (27, 54) 38 (27, 54) 38 (27, 54) 38 (27, 54) 38 (27, 54) 38 (27, 54) 38 (27, 54) 38 (27, 54)
TP53+ TC2 n 30 (20, 39) 13 (9, 28) 15 (9, 18) 10 (6, 18) 0 (0, 1) 3 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.74 (0.71, 0.93) 0.74 (0.53, 0.83) 0.89 (0.66, 0.98) 0.7 (0.57, 0.82) 0.57 (0.55, 0.6) 0.53 (0.51, 0.59) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.019 (0.013, 0.022) 0.019 (0.009, 0.023) 0.007 (0, 0.011) 0.012 (0.005, 0.014) 0 (0, 0) 0 (0, 0.016) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 1 1 1 1 1 1 1 1
TP53+ TC3 time 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33)
TP53+ TC3 n 17 (17, 17) 10 (10, 10) 12 (12, 12) 9 (9, 9) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.7 (0.7, 0.7) 0.72 (0.72, 0.72) 0.75 (0.75, 0.75) 0.5 (0.5, 0.5) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.018 (0.018, 0.018) 0.007 (0.007, 0.007) 0.006 (0.006, 0.006) 0.007 (0.007, 0.007) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 29 29 29 29 29 29 29 29
TP53+ TC4 time 30 (27, 43) 30 (27, 43) 30 (27, 43) 30 (27, 43) 30 (27, 43) 30 (27, 43) 30 (27, 43) 30 (27, 43)
TP53+ TC4 n 22 (14, 32) 11 (8, 19) 12 (9, 17) 9 (6, 16) 0 (0, 1) 2 (1, 4) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.74 (0.72, 0.89) 0.88 (0.64, 0.97) 0.73 (0.54, 0.85) 0.73 (0.6, 0.89) 0.52 (0.51, 0.53) 0.53 (0.51, 0.64) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.016 (0.012, 0.025) 0.005 (0, 0.014) 0.011 (0.003, 0.018) 0 (0, 0.011) 0 (0, 0) 0 (0, 0.017) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 326 326 326 326 326 326 326 326
TEfus+ TC2 time 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55)
TEfus+ TC2 n 5 (2, 9) 22 (16, 40) 18 (10, 28) 14 (8, 27) 9 (5, 16) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.61 (0.52, 0.82) 0.83 (0.71, 0.97) 0.86 (0.71, 0.98) 0.74 (0.57, 0.92) 0.72 (0.53, 0.9) 0.54 (0.51, 0.63) NA (NA, NA) 0.53 (0.52, 0.55)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.005 (0, 0.019) 0.009 (0.003, 0.013) 0.008 (0, 0.013) 0.008 (0, 0.015) 0.007 (0, 0.015) 0 (0, 0.019) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 count 6 6 6 6 6 6 6 6
TEfus+ TC4 time 31 (28, 40) 31 (28, 40) 31 (28, 40) 31 (28, 40) 31 (28, 40) 31 (28, 40) 31 (28, 40) 31 (28, 40)
TEfus+ TC4 n 5 (3, 8) 20 (12, 23) 11 (9, 16) 9 (7, 16) 6 (5, 9) 2 (2, 4) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.57 (0.52, 0.65) 0.83 (0.69, 0.94) 0.66 (0.52, 0.8) 0.74 (0.61, 0.86) 0.54 (0.51, 0.69) 0.55 (0.54, 0.63) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.006 (0, 0.02) 0.004 (0, 0.01) 0.011 (0.007, 0.022) 0.006 (0, 0.009) 0.011 (0, 0.019) 0 (0, 0) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 7 7 7 7 7 7 7 7
PI3K+ TC2 time 35 (27, 43) 35 (27, 43) 35 (27, 43) 35 (27, 43) 35 (27, 43) 35 (27, 43) 35 (27, 43) 35 (27, 43)
PI3K+ TC2 n 12 (9, 14) 23 (17, 30) 13 (9, 23) 12 (8, 15) 0 (0, 0) 2 (1, 4) 3 (2, 8) 0 (0, 0)
PI3K+ TC2 post_p 0.77 (0.53, 0.84) 0.84 (0.8, 0.92) 0.71 (0.56, 0.79) 0.71 (0.63, 0.87) NA (NA, NA) 0.54 (0.52, 0.57) 0.53 (0.51, 0.55) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.014 (0.008, 0.024) 0.005 (0.005, 0.011) 0.014 (0.01, 0.023) 0.007 (0.003, 0.011) NA (NA, NA) 0 (0, 0.016) 0.016 (0, 0.027) NA (NA, NA)
PI3K+ TC4 count 416 416 416 416 416 416 416 416
PI3K+ TC4 time 35 (29, 53) 35 (29, 53) 35 (29, 53) 35 (29, 53) 35 (29, 53) 35 (29, 53) 35 (29, 53) 35 (29, 53)
PI3K+ TC4 n 14 (8, 22) 20 (13, 35) 17 (10, 28) 12 (7, 22) 0 (0, 0) 2 (0, 5) 3 (1, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.85 (0.68, 0.98) 0.82 (0.72, 0.97) 0.9 (0.72, 0.99) 0.75 (0.59, 0.93) NA (NA, NA) 0.54 (0.51, 0.6) 0.55 (0.51, 0.67) 0.53 (0.53, 0.53)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.007 (0, 0.015) 0.007 (0, 0.012) 0.007 (0, 0.015) 0.007 (0, 0.013) 0 (0, 0) 0 (0, 0.018) 0 (0, 0.021) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25
all TC1 time 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59) 45 (14, 59)
all TC1 n 70 (23, 91) 13 (8, 22) 3 (0, 7) 15 (7, 26) 20 (7, 35) 14 (6, 24) 13 (5, 18) 8 (4, 13) 14 (4, 19) 0 (0, 0) 8 (4, 14) 1 (0, 4) 0 (0, 1) 2 (0, 4) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.28 (0.08, 0.47) 0.38 (0.16, 0.49) 0.44 (0.33, 0.47) 0.28 (0.03, 0.42) 0.35 (0.16, 0.46) 0.24 (0.05, 0.46) 0.3 (0.08, 0.48) 0.28 (0.12, 0.44) 0.41 (0.2, 0.49) NA (NA, NA) 0.33 (0.07, 0.47) 0.4 (0.31, 0.47) 0.47 (0.41, 0.49) 0.43 (0.32, 0.49) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.028 (0.024, 0.035) 0.027 (0.019, 0.043) 0.026 (0.016, 0.098) 0.025 (0.016, 0.039) 0.028 (0.022, 0.038) 0.033 (0.024, 0.052) 0.027 (0.017, 0.046) 0.031 (0.019, 0.053) 0.029 (0.02, 0.04) NA (NA, NA) 0.028 (0.018, 0.042) 0.04 (0, 0.677) 0.066 (0, 0.541) 0.035 (0.011, 0.068) NA (NA, NA) NA (NA, NA)
all TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC2 time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
all TC2 n 25 (25, 25) 7 (7, 7) 0 (0, 0) 6 (6, 6) 9 (9, 9) 6 (6, 6) 1 (1, 1) 3 (3, 3) 7 (7, 7) 0 (0, 0) 6 (6, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.3 (0.3, 0.3) 0.45 (0.45, 0.45) NA (NA, NA) 0.49 (0.49, 0.49) 0.4 (0.4, 0.4) 0.41 (0.41, 0.41) 0.4 (0.4, 0.4) 0.5 (0.5, 0.5) 0.32 (0.32, 0.32) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.027 (0.027, 0.027) 0.023 (0.023, 0.023) NA (NA, NA) 0 (0, 0) 0.055 (0.055, 0.055) 0.029 (0.029, 0.029) 0.122 (0.122, 0.122) 0 (0, 0) 0.066 (0.066, 0.066) NA (NA, NA) 0.019 (0.019, 0.019) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC3 time 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19)
all TC3 n 26 (20, 33) 6 (4, 8) 0 (0, 1) 14 (12, 15) 7 (6, 8) 5 (3, 7) 8 (8, 9) 6 (4, 7) 4 (3, 5) 0 (0, 0) 5 (3, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.33 (0.26, 0.4) 0.45 (0.42, 0.48) 0.45 (0.45, 0.45) 0.37 (0.34, 0.4) 0.22 (0.1, 0.34) 0.43 (0.41, 0.44) 0.41 (0.4, 0.42) 0.34 (0.27, 0.42) 0.43 (0.4, 0.45) NA (NA, NA) 0.47 (0.45, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.027 (0.024, 0.029) 0.036 (0.028, 0.045) 0.31 (0.31, 0.31) 0.032 (0.029, 0.035) 0.083 (0.046, 0.121) 0.053 (0.043, 0.064) 0.04 (0.037, 0.044) 0.058 (0.031, 0.085) 0.036 (0.029, 0.042) NA (NA, NA) 0.009 (0.002, 0.016) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 19 19 19 19 19 19 19 19
HRD+ TC1 time 55 (48, 60) 55 (48, 60) 55 (48, 60) 55 (48, 60) 55 (48, 60) 55 (48, 60) 55 (48, 60) 55 (48, 60)
HRD+ TC1 n 25 (21, 32) 0 (0, 0) 16 (14, 20) 5 (2, 7) 0 (0, 2) 6 (2, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.2 (0.08, 0.37) NA (NA, NA) 0.13 (0.03, 0.44) 0.43 (0.32, 0.49) 0.46 (0.45, 0.48) 0.36 (0.18, 0.49) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.03 (0.025, 0.043) NA (NA, NA) 0.027 (0.02, 0.037) 0.029 (0.015, 0.059) 0.057 (0, 0.11) 0.037 (0.021, 0.054) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 11 11 11 11 11 11 11 11
HRD+ TC4 time 57 (54, 59) 57 (54, 59) 57 (54, 59) 57 (54, 59) 57 (54, 59) 57 (54, 59) 57 (54, 59) 57 (54, 59)
HRD+ TC4 n 22 (17, 28) 0 (0, 0) 22 (18, 25) 3 (0, 5) 0 (0, 1) 4 (1, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.37 (0.07, 0.44) NA (NA, NA) 0.06 (0.02, 0.27) 0.46 (0.39, 0.49) 0.45 (0.43, 0.45) 0.44 (0.28, 0.49) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.028 (0.026, 0.04) NA (NA, NA) 0.031 (0.023, 0.038) 0.018 (0.006, 0.043) 0.061 (0.057, 0.071) 0.027 (0.018, 0.053) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 175 175 175 175 175 175 175 175
TP53+ TC1 time 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55)
TP53+ TC1 n 23 (16, 40) 17 (10, 30) 13 (9, 23) 10 (6, 17) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.36 (0.13, 0.48) 0.36 (0.11, 0.48) 0.32 (0.1, 0.48) 0.31 (0.11, 0.46) 0.47 (0.44, 0.5) 0.45 (0.32, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.028 (0.023, 0.037) 0.028 (0.021, 0.045) 0.027 (0.017, 0.04) 0.028 (0.017, 0.043) 0 (0, 0.097) 0.033 (0, 0.086) NA (NA, NA) 0.032 (0.032, 0.032)
TP53+ TC2 count 7 7 7 7 7 7 7 7
TP53+ TC2 time 28 (23, 40) 28 (23, 40) 28 (23, 40) 28 (23, 40) 28 (23, 40) 28 (23, 40) 28 (23, 40) 28 (23, 40)
TP53+ TC2 n 21 (15, 32) 11 (8, 19) 12 (9, 22) 7 (5, 15) 0 (0, 0) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.18 (0.07, 0.35) 0.4 (0.28, 0.47) 0.48 (0.42, 0.49) 0.43 (0.24, 0.48) NA (NA, NA) 0.44 (0.33, 0.48) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.032 (0.025, 0.053) 0.029 (0.017, 0.036) 0.016 (0.014, 0.021) 0.021 (0.02, 0.049) NA (NA, NA) 0.04 (0.024, 0.096) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 140 140 140 140 140 140 140 140
TP53+ TC3 time 34 (26, 51) 34 (26, 51) 34 (26, 51) 34 (26, 51) 34 (26, 51) 34 (26, 51) 34 (26, 51) 34 (26, 51)
TP53+ TC3 n 24 (16, 36) 16 (10, 27) 14 (8, 26) 11 (6, 22) 0 (0, 1) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.37 (0.14, 0.49) 0.32 (0.08, 0.47) 0.29 (0.08, 0.46) 0.29 (0.06, 0.46) 0.48 (0.4, 0.49) 0.48 (0.42, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.029 (0.023, 0.038) 0.031 (0.02, 0.046) 0.029 (0.019, 0.042) 0.029 (0.018, 0.045) 0 (0, 0.104) 0.019 (0, 0.059) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 2 2 2 2 2 2 2 2
TP53+ TC4 time 30 (28, 32) 30 (28, 32) 30 (28, 32) 30 (28, 32) 30 (28, 32) 30 (28, 32) 30 (28, 32) 30 (28, 32)
TP53+ TC4 n 16 (13, 19) 14 (10, 17) 11 (11, 11) 11 (9, 13) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.36 (0.26, 0.45) 0.43 (0.41, 0.46) 0.35 (0.26, 0.45) 0.45 (0.43, 0.46) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.025 (0.02, 0.03) 0.027 (0.022, 0.032) 0.026 (0.022, 0.029) 0.019 (0.018, 0.02) NA (NA, NA) 0.054 (0.054, 0.054) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 304 304 304 304 304 304 304 304
TEfus+ TC1 time 42 (30, 56) 42 (30, 56) 42 (30, 56) 42 (30, 56) 42 (30, 56) 42 (30, 56) 42 (30, 56) 42 (30, 56)
TEfus+ TC1 n 5 (2, 9) 22 (14, 38) 15 (10, 25) 12 (7, 21) 10 (6, 16) 3 (0, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.41 (0.23, 0.48) 0.21 (0.02, 0.45) 0.32 (0.06, 0.47) 0.27 (0.07, 0.45) 0.35 (0.08, 0.48) 0.44 (0.34, 0.49) NA (NA, NA) 0.5 (0.5, 0.5)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.031 (0.017, 0.061) 0.025 (0.017, 0.037) 0.026 (0.018, 0.039) 0.027 (0.017, 0.046) 0.026 (0.015, 0.045) 0.03 (0.005, 0.09) 0 (0, 0) 0.039 (0, 0.144)
TEfus+ TC3 count 51 51 51 51 51 51 51 51
TEfus+ TC3 time 39 (29, 52) 39 (29, 52) 39 (29, 52) 39 (29, 52) 39 (29, 52) 39 (29, 52) 39 (29, 52) 39 (29, 52)
TEfus+ TC3 n 4 (2, 8) 21 (15, 34) 14 (10, 24) 13 (7, 19) 10 (5, 14) 2 (0, 4) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.42 (0.32, 0.49) 0.13 (0.02, 0.37) 0.23 (0.04, 0.47) 0.27 (0.04, 0.41) 0.45 (0.35, 0.5) 0.48 (0.42, 0.5) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.036 (0.02, 0.064) 0.029 (0.023, 0.042) 0.03 (0.022, 0.044) 0.027 (0.02, 0.04) 0.019 (0.012, 0.028) 0.015 (0, 0.043) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 3 3 3 3 3 3 3 3
TEfus+ TC4 time 32 (27, 45) 32 (27, 45) 32 (27, 45) 32 (27, 45) 32 (27, 45) 32 (27, 45) 32 (27, 45) 32 (27, 45)
TEfus+ TC4 n 4 (2, 5) 20 (14, 26) 14 (10, 17) 12 (10, 16) 9 (7, 10) 2 (2, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.38 (0.36, 0.43) 0.46 (0.45, 0.48) 0.32 (0.09, 0.36) 0.45 (0.34, 0.48) 0.41 (0.33, 0.41) 0.44 (0.44, 0.48) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.077 (0.049, 0.12) 0.014 (0.013, 0.016) 0.025 (0.023, 0.036) 0.018 (0.017, 0.028) 0.023 (0.022, 0.066) 0.058 (0.018, 0.073) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 206 206 206 206 206 206 206 206
PI3K+ TC1 time 39 (27, 55) 39 (27, 55) 39 (27, 55) 39 (27, 55) 39 (27, 55) 39 (27, 55) 39 (27, 55) 39 (27, 55)
PI3K+ TC1 n 16 (9, 24) 20 (13, 35) 17 (10, 29) 11 (6, 18) 0 (0, 0) 2 (0, 5) 3 (1, 6) 0 (0, 0)
PI3K+ TC1 post_p 0.36 (0.13, 0.47) 0.22 (0.04, 0.43) 0.34 (0.12, 0.48) 0.3 (0.09, 0.47) NA (NA, NA) 0.44 (0.35, 0.49) 0.44 (0.34, 0.49) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.029 (0.022, 0.042) 0.025 (0.018, 0.038) 0.028 (0.021, 0.043) 0.028 (0.016, 0.044) NA (NA, NA) 0.029 (0, 0.088) 0.032 (0.011, 0.083) 0 (0, 0)
PI3K+ TC2 count 5 5 5 5 5 5 5 5
PI3K+ TC2 time 30 (24, 38) 30 (24, 38) 30 (24, 38) 30 (24, 38) 30 (24, 38) 30 (24, 38) 30 (24, 38) 30 (24, 38)
PI3K+ TC2 n 11 (8, 17) 19 (15, 20) 14 (11, 19) 8 (5, 9) 0 (0, 0) 3 (1, 4) 3 (1, 4) 0 (0, 0)
PI3K+ TC2 post_p 0.23 (0.12, 0.38) 0.45 (0.37, 0.48) 0.29 (0.23, 0.43) 0.48 (0.44, 0.5) NA (NA, NA) 0.49 (0.47, 0.5) 0.45 (0.42, 0.49) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.04 (0.035, 0.047) 0.015 (0.011, 0.019) 0.03 (0.024, 0.031) 0.02 (0.019, 0.022) NA (NA, NA) 0 (0, 0.031) 0.046 (0.015, 0.172) NA (NA, NA)
PI3K+ TC3 count 101 101 101 101 101 101 101 101
PI3K+ TC3 time 35 (25, 48) 35 (25, 48) 35 (25, 48) 35 (25, 48) 35 (25, 48) 35 (25, 48) 35 (25, 48) 35 (25, 48)
PI3K+ TC3 n 13 (8, 21) 20 (14, 29) 16 (11, 25) 11 (7, 16) 0 (0, 0) 2 (0, 4) 2 (0, 4) 0 (0, 0)
PI3K+ TC3 post_p 0.33 (0.14, 0.47) 0.2 (0.04, 0.41) 0.3 (0.12, 0.46) 0.35 (0.07, 0.48) NA (NA, NA) 0.47 (0.42, 0.5) 0.48 (0.42, 0.5) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.029 (0.022, 0.041) 0.028 (0.019, 0.037) 0.03 (0.022, 0.044) 0.027 (0.016, 0.047) NA (NA, NA) 0.019 (0, 0.063) 0.02 (0, 0.065) 0 (0, 0)