Equal randomization: several treatments more effective in distinctive signatures (cfr scen 6)
| signature | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.026, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.025, shape = 1.3 |
| all | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 35.8, median = 29.3 | mean = 32, median = 26.2 | mean = 36.8, median = 30.1 |
| all | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.92, hr = 1.12 | af = 0.82, hr = 1.29 | af = 0.94, hr = 1.08 |
| HRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.028, shape = 1.3 |
| HRD+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 37.9, median = 31 | mean = 78.1, median = 63.8 | mean = 32.9, median = 26.9 |
| HRD+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.97, hr = 1.04 | af = 2, hr = 0.41 | af = 0.84, hr = 1.25 |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.025, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.023, shape = 1.3 |
| TP53+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 37.2, median = 30.4 | mean = 30.2, median = 24.7 | mean = 39.4, median = 32.2 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.95, hr = 1.07 | af = 0.77, hr = 1.4 | af = 1.01, hr = 0.99 |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.028, shape = 1.3 | scale = 0.021, shape = 1.3 |
| TEfus+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 72.6, median = 59.3 | mean = 32.8, median = 26.8 | mean = 43.2, median = 35.3 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.86, hr = 0.45 | af = 0.84, hr = 1.25 | af = 1.11, hr = 0.88 |
| PI3K+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.023, shape = 1.3 | scale = 0.03, shape = 1.3 | scale = 0.012, shape = 1.3 |
| PI3K+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 40.6, median = 33.2 | mean = 30.7, median = 25.1 | mean = 78.4, median = 64 |
| PI3K+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.04, hr = 0.95 | af = 0.79, hr = 1.36 | af = 2.01, hr = 0.4 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| —- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| —- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| —+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| —+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 |
| —+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 |
| –+- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| –+- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| –+- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| –++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| –++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 |
| –++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 |
| -+– | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| -+– | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| -+– | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| -+-+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| -+-+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 |
| -+-+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 |
| -++- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| -++- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| -++- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| -+++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| -+++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 29.4, median = 24 | mean = 79.9, median = 65.3 |
| -+++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 0.75, hr = 1.44 | af = 2.05, hr = 0.39 |
| +— | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| +— | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| +— | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| +–+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| +–+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| +–+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
| +-+- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| +-+- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| +-+- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| +-++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| +-++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| +-++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
| ++– | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| ++– | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| ++– | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| ++-+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| ++-+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| ++-+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
| +++- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| +++- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| +++- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| ++++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| ++++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| ++++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
|
|
|
|
|
|
| Characteristics | Overall | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| Error signature | 0.086 | 0.012 | 0.046 | 0.014 | 0.020 |
| Error subgroup | 0.168 | 0.012 | 0.072 | 0.014 | 0.084 |
| Power signature | 0.952 | 0.000 | 0.652 | 0.240 | 0.832 |
| Power subgroup | 0.956 | 0.000 | 0.698 | 0.254 | 0.852 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 5 | 17 | 6 | 11 |
| all | futility | 0 | 25 | 1 | 2 | 0 |
| all | max_n | 0 | 0 | 0 | 0 | 0 |
| all | n | 586 (559, 611) | 278 (218, 349) | 316 (255, 386) | 325 (240, 400) | 285 (245, 355) |
| all | n_unique | 586 (559, 611) | 278 (218, 349) | 316 (255, 386) | 325 (240, 400) | 285 (245, 355) |
| all | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) |
| all | time_stop | NA (NA, NA) | 42 (11, 58) | 12 (11, 32) | 16 (13, 19) | 20 (13, 48) |
| all | post_p | NA (NA, NA) | 0.06 (0, 0.39) | 0.73 (0.27, 0.97) | 0.15 (0.01, 0.55) | 0.83 (0.43, 0.98) |
| all | rate | 0.023 (0.022, 0.025) | 0.027 (0.025, 0.03) | 0.022 (0.02, 0.024) | 0.025 (0.023, 0.028) | 0.021 (0.019, 0.024) |
| HRD+ | graduation | 0 | 0 | 4 | 120 | 0 |
| HRD+ | futility | 0 | 19 | 0 | 0 | 11 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 85 (73, 98) | 40 (29, 52) | 42 (31, 54) | 47 (35, 53) | 44 (35, 56) |
| HRD+ | n_unique | 85 (73, 98) | 40 (29, 52) | 42 (31, 54) | 47 (35, 53) | 44 (35, 56) |
| HRD+ | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (54, 60) | 60 (60, 60) |
| HRD+ | time_stop | NA (NA, NA) | 55 (48, 60) | 58 (54, 60) | 55 (49, 59) | 57 (54, 59) |
| HRD+ | post_p | NA (NA, NA) | 0.22 (0.03, 0.64) | 0.6 (0.23, 0.9) | 1 (0.96, 1) | 0.32 (0.04, 0.76) |
| HRD+ | rate | 0.023 (0.019, 0.027) | 0.027 (0.021, 0.035) | 0.021 (0.015, 0.026) | 0.009 (0.006, 0.013) | 0.025 (0.019, 0.032) |
| TP53+ | graduation | 0 | 1 | 11 | 1 | 29 |
| TP53+ | futility | 0 | 175 | 7 | 140 | 2 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 220 (198, 239) | 100 (53, 140) | 122 (89, 166) | 120 (58, 161) | 108 (82, 146) |
| TP53+ | n_unique | 220 (198, 239) | 100 (53, 140) | 122 (89, 166) | 120 (58, 161) | 108 (82, 146) |
| TP53+ | time_trial | 60 (60, 60) | 60 (29, 60) | 60 (60, 60) | 60 (32, 60) | 60 (60, 60) |
| TP53+ | time_stop | NA (NA, NA) | 36 (26, 54) | 31 (25, 54) | 34 (26, 51) | 30 (27, 42) |
| TP53+ | post_p | NA (NA, NA) | 0.16 (0.01, 0.57) | 0.72 (0.29, 0.96) | 0.08 (0, 0.38) | 0.83 (0.43, 0.99) |
| TP53+ | rate | 0.023 (0.02, 0.025) | 0.027 (0.023, 0.033) | 0.021 (0.017, 0.024) | 0.029 (0.024, 0.034) | 0.02 (0.017, 0.023) |
| TEfus+ | graduation | 0 | 0 | 326 | 0 | 6 |
| TEfus+ | futility | 0 | 304 | 0 | 51 | 3 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 190 (170, 209) | 80 (51, 125) | 86 (51, 136) | 116 (67, 166) | 94 (69, 133) |
| TEfus+ | n_unique | 190 (170, 209) | 80 (51, 125) | 86 (51, 136) | 116 (67, 166) | 94 (69, 133) |
| TEfus+ | time_trial | 60 (60, 60) | 53 (32, 60) | 50 (32, 60) | 60 (60, 60) | 60 (60, 60) |
| TEfus+ | time_stop | NA (NA, NA) | 42 (30, 56) | 40 (30, 55) | 39 (29, 52) | 32 (28, 45) |
| TEfus+ | post_p | NA (NA, NA) | 0.01 (0, 0.17) | 1 (0.97, 1) | 0.03 (0, 0.27) | 0.6 (0.17, 0.94) |
| TEfus+ | rate | 0.018 (0.016, 0.021) | 0.027 (0.023, 0.033) | 0.01 (0.008, 0.012) | 0.025 (0.021, 0.029) | 0.018 (0.014, 0.021) |
| PI3K+ | graduation | 0 | 0 | 7 | 0 | 416 |
| PI3K+ | futility | 0 | 206 | 5 | 101 | 0 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 205 (185, 223) | 94 (53, 138) | 117 (78, 166) | 126 (60, 175) | 72 (51, 127) |
| PI3K+ | n_unique | 205 (185, 223) | 94 (53, 138) | 117 (78, 166) | 126 (60, 175) | 72 (51, 127) |
| PI3K+ | time_trial | 60 (60, 60) | 60 (31, 60) | 60 (60, 60) | 60 (35, 60) | 38 (29, 60) |
| PI3K+ | time_stop | NA (NA, NA) | 39 (27, 55) | 33 (26, 42) | 35 (25, 48) | 35 (29, 53) |
| PI3K+ | post_p | NA (NA, NA) | 0.09 (0, 0.43) | 0.8 (0.34, 0.98) | 0.05 (0, 0.34) | 1 (1, 1) |
| PI3K+ | rate | 0.022 (0.019, 0.024) | 0.027 (0.023, 0.033) | 0.019 (0.016, 0.022) | 0.028 (0.023, 0.033) | 0.009 (0.007, 0.012) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 5 | 17 | 6 | 11 |
| —- | futility | 0 | 25 | 1 | 2 | 0 |
| —- | max_n | 0 | 0 | 0 | 0 | 0 |
| —- | n | 177 (160, 194) | 91 (75, 106) | 92 (78, 105) | 91 (79, 107) | 91 (78, 105) |
| —- | n_unique | 177 (160, 194) | 91 (75, 106) | 92 (78, 105) | 91 (79, 107) | 91 (78, 105) |
| —- | post_p | NA (NA, NA) | 0.43 (0.08, 0.86) | 0.22 (0.02, 0.65) | 0.23 (0.02, 0.69) | 0.23 (0.03, 0.67) |
| —- | rate | 0.026 (0.023, 0.029) | 0.027 (0.023, 0.032) | 0.03 (0.025, 0.035) | 0.029 (0.025, 0.035) | 0.029 (0.025, 0.034) |
| —+ | graduation | 0 | 5 | 22 | 6 | 423 |
| —+ | futility | 0 | 213 | 6 | 103 | 0 |
| —+ | max_n | 0 | 0 | 0 | 0 | 0 |
| —+ | n | 42 (34, 50) | 22 (11, 32) | 26 (17, 37) | 24 (13, 33) | 15 (8, 25) |
| —+ | n_unique | 42 (34, 50) | 22 (11, 32) | 26 (17, 37) | 24 (13, 33) | 15 (8, 25) |
| —+ | post_p | NA (NA, NA) | 0.41 (0.13, 0.79) | 0.3 (0.05, 0.73) | 0.29 (0.07, 0.68) | 0.98 (0.87, 1) |
| —+ | rate | 0.026 (0.02, 0.034) | 0.027 (0.019, 0.038) | 0.029 (0.021, 0.041) | 0.03 (0.021, 0.04) | 0.009 (0.004, 0.015) |
| –+- | graduation | 0 | 5 | 341 | 6 | 17 |
| –+- | futility | 0 | 312 | 1 | 53 | 3 |
| –+- | max_n | 0 | 0 | 0 | 0 | 0 |
| –+- | n | 13 (8, 19) | 6 (3, 10) | 6 (2, 10) | 7 (4, 12) | 8 (4, 13) |
| –+- | n_unique | 13 (8, 19) | 6 (3, 10) | 6 (2, 10) | 7 (4, 12) | 8 (4, 13) |
| –+- | post_p | NA (NA, NA) | 0.37 (0.14, 0.68) | 0.73 (0.49, 0.93) | 0.35 (0.11, 0.62) | 0.35 (0.1, 0.64) |
| –+- | rate | 0.018 (0.009, 0.031) | 0.029 (0.012, 0.057) | 0.009 (0, 0.023) | 0.03 (0.016, 0.057) | 0.03 (0.015, 0.053) |
| –++ | graduation | 0 | 5 | 344 | 6 | 424 |
| –++ | futility | 0 | 376 | 3 | 135 | 2 |
| –++ | max_n | 0 | 0 | 0 | 0 | 0 |
| –++ | n | 61 (49, 72) | 25 (14, 45) | 27 (16, 47) | 40 (18, 64) | 21 (13, 41) |
| –++ | n_unique | 61 (49, 72) | 25 (14, 45) | 27 (16, 47) | 40 (18, 64) | 21 (13, 41) |
| –++ | post_p | NA (NA, NA) | 0.11 (0.01, 0.44) | 0.93 (0.66, 0.99) | 0.04 (0, 0.29) | 0.96 (0.79, 1) |
| –++ | rate | 0.018 (0.014, 0.023) | 0.027 (0.02, 0.038) | 0.01 (0.006, 0.015) | 0.03 (0.022, 0.039) | 0.009 (0.005, 0.013) |
| -+– | graduation | 0 | 6 | 27 | 6 | 38 |
| -+– | futility | 0 | 182 | 8 | 142 | 2 |
| -+– | max_n | 0 | 0 | 0 | 0 | 0 |
| -+– | n | 76 (65, 87) | 36 (18, 48) | 42 (30, 56) | 37 (20, 49) | 41 (29, 54) |
| -+– | n_unique | 76 (65, 87) | 36 (18, 48) | 42 (30, 56) | 37 (20, 49) | 41 (29, 54) |
| -+– | post_p | NA (NA, NA) | 0.47 (0.14, 0.85) | 0.35 (0.05, 0.78) | 0.35 (0.07, 0.74) | 0.33 (0.05, 0.74) |
| -+– | rate | 0.026 (0.021, 0.031) | 0.028 (0.02, 0.036) | 0.029 (0.023, 0.038) | 0.03 (0.023, 0.038) | 0.03 (0.023, 0.038) |
| -+-+ | graduation | 0 | 5 | 32 | 6 | 426 |
| -+-+ | futility | 0 | 274 | 13 | 174 | 2 |
| -+-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+-+ | n | 52 (42, 61) | 24 (11, 38) | 34 (20, 51) | 28 (13, 41) | 18 (10, 31) |
| -+-+ | n_unique | 52 (42, 61) | 24 (11, 38) | 34 (20, 51) | 28 (13, 41) | 18 (10, 31) |
| -+-+ | post_p | NA (NA, NA) | 0.4 (0.1, 0.84) | 0.3 (0.04, 0.74) | 0.31 (0.05, 0.73) | 0.99 (0.91, 1) |
| -+-+ | rate | 0.026 (0.02, 0.032) | 0.028 (0.019, 0.04) | 0.029 (0.021, 0.039) | 0.03 (0.022, 0.041) | 0.009 (0.005, 0.015) |
| -++- | graduation | 0 | 5 | 344 | 6 | 42 |
| -++- | futility | 0 | 370 | 5 | 174 | 5 |
| -++- | max_n | 0 | 0 | 0 | 0 | 0 |
| -++- | n | 46 (37, 55) | 18 (10, 31) | 20 (10, 32) | 25 (12, 37) | 30 (17, 43) |
| -++- | n_unique | 46 (37, 55) | 18 (10, 31) | 20 (10, 32) | 25 (12, 37) | 30 (17, 43) |
| -++- | post_p | NA (NA, NA) | 0.21 (0.03, 0.56) | 0.94 (0.76, 1) | 0.11 (0.01, 0.43) | 0.1 (0.01, 0.45) |
| -++- | rate | 0.018 (0.013, 0.024) | 0.028 (0.019, 0.039) | 0.009 (0.004, 0.014) | 0.03 (0.021, 0.041) | 0.03 (0.021, 0.039) |
| -+++ | graduation | 0 | 5 | 347 | 6 | 426 |
| -+++ | futility | 0 | 399 | 7 | 203 | 4 |
| -+++ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+++ | n | 35 (25, 44) | 13 (7, 28) | 17 (7, 33) | 21 (8, 40) | 14 (7, 26) |
| -+++ | n_unique | 35 (25, 44) | 13 (7, 28) | 17 (7, 33) | 21 (8, 40) | 14 (7, 26) |
| -+++ | post_p | NA (NA, NA) | 0.16 (0.03, 0.53) | 0.86 (0.57, 0.98) | 0.11 (0.01, 0.38) | 0.9 (0.61, 0.98) |
| -+++ | rate | 0.018 (0.013, 0.024) | 0.028 (0.019, 0.043) | 0.01 (0.005, 0.016) | 0.03 (0.021, 0.043) | 0.009 (0.004, 0.016) |
| +— | graduation | 0 | 5 | 21 | 126 | 11 |
| +— | futility | 0 | 44 | 1 | 2 | 11 |
| +— | max_n | 0 | 0 | 0 | 0 | 0 |
| +— | n | 39 (32, 48) | 20 (14, 27) | 21 (14, 27) | 20 (14, 26) | 21 (15, 27) |
| +— | n_unique | 39 (32, 48) | 20 (14, 27) | 21 (14, 27) | 20 (14, 26) | 21 (15, 27) |
| +— | post_p | NA (NA, NA) | 0.41 (0.1, 0.81) | 0.34 (0.08, 0.71) | 0.98 (0.88, 1) | 0.33 (0.06, 0.76) |
| +— | rate | 0.026 (0.02, 0.034) | 0.027 (0.019, 0.039) | 0.029 (0.02, 0.041) | 0.009 (0.004, 0.015) | 0.029 (0.021, 0.042) |
| +–+ | graduation | 0 | 5 | 26 | 125 | 416 |
| +–+ | futility | 0 | 223 | 6 | 98 | 10 |
| +–+ | max_n | 0 | 0 | 0 | 0 | 0 |
| +–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.47 (0.47, 0.47) | NA (NA, NA) |
| +–+ | rate | 0 (0, 0) | NA (NA, NA) | 0.027 (0.005, 0.112) | 0 (0, 0.07) | 0.025 (0.005, 0.045) |
| +-+- | graduation | 0 | 5 | 343 | 126 | 17 |
| +-+- | futility | 0 | 324 | 1 | 53 | 14 |
| +-+- | max_n | 0 | 0 | 0 | 0 | 0 |
| +-+- | n | 28 (21, 35) | 12 (6, 19) | 11 (5, 19) | 16 (10, 22) | 17 (11, 24) |
| +-+- | n_unique | 28 (21, 35) | 12 (6, 19) | 11 (5, 19) | 16 (10, 22) | 17 (11, 24) |
| +-+- | post_p | NA (NA, NA) | 0.22 (0.04, 0.57) | 0.78 (0.5, 0.95) | 0.85 (0.56, 0.98) | 0.17 (0.02, 0.51) |
| +-+- | rate | 0.018 (0.012, 0.025) | 0.027 (0.017, 0.043) | 0.01 (0.003, 0.018) | 0.009 (0.003, 0.017) | 0.029 (0.018, 0.042) |
| +-++ | graduation | 0 | 5 | 346 | 125 | 417 |
| +-++ | futility | 0 | 382 | 3 | 130 | 12 |
| +-++ | max_n | 0 | 0 | 0 | 0 | 0 |
| +-++ | n | 6 (4, 10) | 3 (1, 6) | 3 (1, 6) | 4 (1, 8) | 3 (0, 6) |
| +-++ | n_unique | 6 (4, 10) | 3 (1, 6) | 3 (1, 6) | 4 (1, 8) | 3 (0, 6) |
| +-++ | post_p | NA (NA, NA) | 0.41 (0.24, 0.54) | 0.54 (0.42, 0.67) | 0.56 (0.44, 0.74) | 0.55 (0.43, 0.67) |
| +-++ | rate | 0.019 (0.007, 0.041) | 0.029 (0.009, 0.081) | 0.008 (0, 0.031) | 0.007 (0, 0.024) | 0.008 (0, 0.03) |
| ++– | graduation | 0 | 6 | 31 | 121 | 38 |
| ++– | futility | 0 | 196 | 8 | 132 | 13 |
| ++– | max_n | 0 | 0 | 0 | 0 | 0 |
| ++– | n | 1 (0, 3) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) |
| ++– | n_unique | 1 (0, 3) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) |
| ++– | post_p | NA (NA, NA) | 0.48 (0.43, 0.55) | 0.49 (0.42, 0.57) | 0.54 (0.45, 0.59) | 0.49 (0.42, 0.57) |
| ++– | rate | 0.026 (0, 0.081) | 0.029 (0, 0.137) | 0.025 (0, 0.123) | 0 (0, 0.049) | 0.029 (0, 0.124) |
| ++-+ | graduation | 0 | 5 | 36 | 121 | 419 |
| ++-+ | futility | 0 | 282 | 13 | 162 | 12 |
| ++-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++-+ | n | 9 (5, 13) | 4 (1, 8) | 6 (2, 10) | 4 (1, 8) | 3 (1, 6) |
| ++-+ | n_unique | 9 (5, 13) | 4 (1, 8) | 6 (2, 10) | 4 (1, 8) | 3 (1, 6) |
| ++-+ | post_p | NA (NA, NA) | 0.44 (0.25, 0.65) | 0.43 (0.21, 0.64) | 0.65 (0.44, 0.89) | 0.63 (0.45, 0.85) |
| ++-+ | rate | 0.027 (0.013, 0.044) | 0.027 (0.009, 0.069) | 0.03 (0.011, 0.06) | 0.009 (0, 0.027) | 0.009 (0, 0.026) |
| +++- | graduation | 0 | 5 | 346 | 121 | 42 |
| +++- | futility | 0 | 378 | 5 | 164 | 16 |
| +++- | max_n | 0 | 0 | 0 | 0 | 0 |
| +++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | post_p | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.55 (0.55, 0.55) | 0.44 (0.44, 0.44) |
| +++- | rate | 0.014 (0, 0.242) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.018 (0.004, 0.033) |
| ++++ | graduation | 0 | 5 | 349 | 121 | 419 |
| ++++ | futility | 0 | 404 | 7 | 191 | 14 |
| ++++ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | post_p | NA (NA, NA) | 0.5 (0.49, 0.51) | 0.53 (0.51, 0.55) | 0.51 (0.51, 0.51) | 0.54 (0.54, 0.54) |
| ++++ | rate | 0 (0, 0.121) | 0.037 (0, 0.109) | 0 (0, 0.038) | 0 (0, 0) | 0 (0, 0.046) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| all | count | 5 | 17 | 6 | 11 |
| all | time_stop | 11 (10, 15) | 12 (11, 33) | 16 (12, 18) | 20 (13, 48) |
| all | n_trt | 57 (52, 71) | 64 (53, 161) | 83 (62, 100) | 108 (67, 238) |
| all | n_control | 110 (103, 131) | 112 (93, 307) | 143 (110, 168) | 193 (120, 462) |
| all | post_p | 0.93 (0.91, 0.97) | 0.93 (0.87, 0.99) | 0.96 (0.86, 0.98) | 0.98 (0.91, 1) |
| all | order | 1 (1, 1) | 1 (1, 2) | 1 (1, 1) | 1 (1, 2) |
| HRD+ | count | 4 | 120 | ||
| HRD+ | time_stop | 58 (54, 60) | 55 (49, 59) | ||
| HRD+ | n_trt | 54 (51, 60) | 51 (50, 54) | ||
| HRD+ | n_control | 77 (73, 84) | 78 (64, 96) | ||
| HRD+ | post_p | 0.93 (0.89, 0.97) | 1 (0.98, 1) | ||
| HRD+ | order | 2.5 (2, 3) | 3 (2, 3) | ||
| TP53+ | count | 1 | 11 | 1 | 29 |
| TP53+ | time_stop | 24 (24, 24) | 38 (27, 54) | 33 (33, 33) | 30 (27, 43) |
| TP53+ | n_trt | 52 (52, 52) | 74 (55, 98) | 50 (50, 50) | 55 (50, 83) |
| TP53+ | n_control | 86 (86, 86) | 137 (109, 185) | 122 (122, 122) | 117 (91, 166) |
| TP53+ | post_p | 0.88 (0.88, 0.88) | 0.97 (0.9, 0.99) | 0.96 (0.96, 0.96) | 0.98 (0.9, 1) |
| TP53+ | order | 1 (1, 1) | 2 (1, 3) | 1 (1, 1) | 1 (1, 2) |
| TEfus+ | count | 326 | 6 | ||
| TEfus+ | time_stop | 40 (30, 55) | 31 (28, 40) | ||
| TEfus+ | n_trt | 70 (51, 117) | 55 (52, 58) | ||
| TEfus+ | n_control | 128 (92, 176) | 102 (88, 136) | ||
| TEfus+ | post_p | 0.99 (0.96, 1) | 0.99 (0.92, 1) | ||
| TEfus+ | order | 2 (1, 2) | 1 (1, 3.5) | ||
| PI3K+ | count | 7 | 416 | ||
| PI3K+ | time_stop | 35 (27, 43) | 35 (29, 53) | ||
| PI3K+ | n_trt | 61 (55, 85) | 65 (51, 112) | ||
| PI3K+ | n_control | 121 (84, 144) | 121 (91, 182) | ||
| PI3K+ | post_p | 0.98 (0.96, 0.99) | 1 (0.98, 1) | ||
| PI3K+ | order | 2 (1, 4) | 1 (1, 2) |
| signature | var | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| all | count | 25 | 1 | 2 | |
| all | time_stop | 45 (14, 59) | 12 (12, 12) | 17 (15, 19) | |
| all | n_trt | 197 (75, 244) | 70 (70, 70) | 81 (79, 83) | |
| all | n_control | 453 (125, 575) | 105 (105, 105) | 148 (120, 176) | |
| all | post_p | 0.01 (0, 0.04) | 0.04 (0.04, 0.04) | 0.02 (0.01, 0.03) | |
| all | order | 3 (1, 5) | 1 (1, 1) | 1 (1, 1) | |
| HRD+ | count | 19 | 11 | ||
| HRD+ | time_stop | 55 (48, 60) | 57 (54, 59) | ||
| HRD+ | n_trt | 50 (50, 57) | 51 (50, 53) | ||
| HRD+ | n_control | 72 (62, 90) | 84 (76, 91) | ||
| HRD+ | post_p | 0.04 (0.01, 0.16) | 0.06 (0.01, 0.09) | ||
| HRD+ | order | 2 (1, 4) | 3 (2, 6) | ||
| TP53+ | count | 175 | 7 | 140 | 2 |
| TP53+ | time_stop | 36 (26, 55) | 28 (23, 40) | 34 (26, 51) | 30 (28, 32) |
| TP53+ | n_trt | 67 (51, 110) | 50 (50, 85) | 68 (51, 111) | 52 (51, 54) |
| TP53+ | n_control | 129 (91, 204) | 101 (81, 144) | 124 (88, 194) | 112 (104, 121) |
| TP53+ | post_p | 0.09 (0.02, 0.2) | 0.11 (0.05, 0.23) | 0.07 (0.01, 0.18) | 0.15 (0.13, 0.17) |
| TP53+ | order | 2 (1, 3) | 1 (1, 2.2) | 2 (1, 3) | 1 (1, 1) |
| TEfus+ | count | 304 | 51 | 3 | |
| TEfus+ | time_stop | 42 (30, 56) | 39 (29, 52) | 32 (27, 45) | |
| TEfus+ | n_trt | 66 (51, 105) | 66 (50, 97) | 54 (53, 74) | |
| TEfus+ | n_control | 131 (92, 177) | 127 (92, 161) | 115 (101, 138) | |
| TEfus+ | post_p | 0.03 (0, 0.13) | 0.02 (0, 0.14) | 0.07 (0.06, 0.07) | |
| TEfus+ | order | 2 (1, 3) | 2 (1, 4) | 1 (1, 1.8) | |
| PI3K+ | count | 206 | 5 | 101 | |
| PI3K+ | time_stop | 39 (27, 55) | 30 (24, 38) | 35 (25, 48) | |
| PI3K+ | n_trt | 68 (51, 106) | 53 (52, 65) | 62 (51, 95) | |
| PI3K+ | n_control | 130 (87, 188) | 95 (86, 124) | 116 (85, 165) | |
| PI3K+ | post_p | 0.05 (0.01, 0.18) | 0.17 (0.08, 0.18) | 0.05 (0.01, 0.17) | |
| PI3K+ | order | 2 (1, 3.5) | 2 (1, 2) | 2 (1, 4) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| all | TC1 | time | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) | 11 (10, 15) |
| all | TC1 | n | 20 (17, 27) | 6 (3, 7) | 2 (0, 3) | 8 (3, 10) | 6 (3, 9) | 4 (4, 6) | 3 (1, 4) | 3 (1, 6) | 4 (3, 5) | 0 (0, 0) | 2 (1, 3) | 1 (0, 3) | 0 (0, 1) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.74 (0.58, 0.76) | 0.54 (0.5, 0.67) | 0.53 (0.52, 0.55) | 0.52 (0.51, 0.56) | 0.55 (0.51, 0.57) | 0.53 (0.52, 0.55) | 0.54 (0.52, 0.57) | 0.53 (0.51, 0.54) | 0.52 (0.51, 0.53) | NA (NA, NA) | 0.54 (0.53, 0.55) | 0.53 (0.52, 0.53) | NA (NA, NA) | 0.53 (0.51, 0.54) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.27 (0.27, 0.27) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.008 (0.002, 0.013) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.014) | 0 (0, 0.007) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.036) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 |
| all | TC2 | time | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) | 12 (11, 33) |
| all | TC2 | n | 23 (15, 49) | 5 (2, 11) | 2 (0, 6) | 10 (6, 16) | 9 (4, 23) | 6 (3, 11) | 5 (3, 13) | 6 (3, 9) | 4 (2, 9) | 0 (0, 0) | 3 (1, 7) | 0 (0, 2) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.61 (0.55, 0.72) | 0.54 (0.51, 0.59) | 0.52 (0.5, 0.59) | 0.6 (0.52, 0.85) | 0.57 (0.51, 0.74) | 0.53 (0.5, 0.75) | 0.57 (0.52, 0.82) | 0.55 (0.51, 0.78) | 0.52 (0.51, 0.57) | NA (NA, NA) | 0.54 (0.51, 0.64) | 0.52 (0.51, 0.52) | NA (NA, NA) | 0.51 (0.5, 0.55) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.014 (0, 0.024) | 0 (0, 0.018) | 0 (0, 0.013) | 0 (0, 0.009) | 0.012 (0, 0.021) | 0 (0, 0.036) | 0 (0, 0.006) | 0 (0, 0.008) | 0 (0, 0.021) | NA (NA, NA) | 0 (0, 0.004) | 0 (0, 0.005) | 0 (0, 0) | 0 (0, 0.037) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| all | TC3 | time | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) |
| all | TC3 | n | 28 (18, 32) | 5 (2, 10) | 2 (0, 4) | 8 (5, 11) | 8 (6, 20) | 7 (2, 10) | 6 (2, 9) | 5 (3, 8) | 5 (4, 6) | 0 (0, 0) | 4 (2, 7) | 0 (0, 1) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.64 (0.54, 0.89) | 0.55 (0.52, 0.58) | 0.54 (0.51, 0.58) | 0.53 (0.51, 0.6) | 0.55 (0.52, 0.75) | 0.52 (0.51, 0.54) | 0.52 (0.51, 0.55) | 0.54 (0.52, 0.58) | 0.53 (0.52, 0.56) | NA (NA, NA) | 0.57 (0.53, 0.6) | 0.55 (0.54, 0.56) | NA (NA, NA) | 0.53 (0.52, 0.54) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.011 (0.002, 0.021) | 0 (0, 0.006) | 0 (0, 0.043) | 0.005 (0, 0.022) | 0.008 (0, 0.018) | 0.006 (0, 0.017) | 0 (0, 0.016) | 0 (0, 0) | 0 (0, 0.006) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 |
| all | TC4 | time | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) | 20 (13, 48) |
| all | TC4 | n | 36 (20, 63) | 8 (5, 16) | 2 (0, 5) | 12 (7, 20) | 14 (8, 25) | 9 (4, 13) | 6 (4, 14) | 7 (2, 18) | 9 (2, 12) | 0 (0, 0) | 4 (2, 12) | 0 (0, 4) | 0 (0, 1) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.63 (0.55, 0.7) | 0.62 (0.51, 0.98) | 0.54 (0.52, 0.55) | 0.62 (0.5, 0.79) | 0.62 (0.52, 0.8) | 0.62 (0.54, 0.95) | 0.54 (0.52, 0.7) | 0.6 (0.54, 0.7) | 0.57 (0.5, 0.65) | NA (NA, NA) | 0.55 (0.53, 0.62) | 0.53 (0.51, 0.59) | 0.52 (0.51, 0.53) | 0.54 (0.51, 0.57) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.018 (0.009, 0.024) | 0.005 (0, 0.016) | 0 (0, 0.013) | 0 (0, 0.01) | 0.017 (0, 0.024) | 0.007 (0, 0.013) | 0 (0, 0.019) | 0 (0, 0.015) | 0 (0, 0.025) | 0 (0, 0) | 0 (0, 0.013) | 0 (0, 0.021) | 0 (0, 0) | 0 (0, 0.004) | NA (NA, NA) | NA (NA, NA) |
| HRD+ | TC2 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||
| HRD+ | TC2 | time | 58 (54, 60) | 58 (54, 60) | 58 (54, 60) | 58 (54, 60) | 58 (54, 60) | 58 (54, 60) | 58 (54, 60) | 58 (54, 60) | ||||||||
| HRD+ | TC2 | n | 24 (22, 29) | 0 (0, 0) | 18 (16, 21) | 4 (3, 5) | 0 (0, 1) | 9 (3, 10) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | post_p | 0.84 (0.81, 0.91) | NA (NA, NA) | 0.79 (0.73, 0.85) | 0.62 (0.54, 0.63) | 0.52 (0.52, 0.52) | 0.62 (0.57, 0.65) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | rate | 0.018 (0.013, 0.021) | NA (NA, NA) | 0.009 (0.007, 0.011) | 0.006 (0, 0.019) | 0 (0, 0) | 0.022 (0.006, 0.023) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC3 | count | 120 | 120 | 120 | 120 | 120 | 120 | 120 | 120 | ||||||||
| HRD+ | TC3 | time | 55 (49, 59) | 55 (49, 59) | 55 (49, 59) | 55 (49, 59) | 55 (49, 59) | 55 (49, 59) | 55 (49, 59) | 55 (49, 59) | ||||||||
| HRD+ | TC3 | n | 21 (17, 27) | 0 (0, 0) | 18 (14, 23) | 5 (2, 9) | 0 (0, 2) | 5 (3, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC3 | post_p | 0.98 (0.81, 1) | NA (NA, NA) | 0.9 (0.74, 0.97) | 0.58 (0.52, 0.7) | 0.54 (0.52, 0.6) | 0.68 (0.53, 0.91) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC3 | r_prob | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| HRD+ | TC3 | rate | 0.009 (0.005, 0.014) | 0 (0, 0.08) | 0.007 (0.002, 0.013) | 0 (0, 0.016) | 0 (0, 0.02) | 0.006 (0, 0.016) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| TP53+ | TC1 | time | 24 (24, 24) | 24 (24, 24) | 24 (24, 24) | 24 (24, 24) | 24 (24, 24) | 24 (24, 24) | 24 (24, 24) | 24 (24, 24) | ||||||||
| TP53+ | TC1 | n | 27 (27, 27) | 10 (10, 10) | 7 (7, 7) | 5 (5, 5) | 0 (0, 0) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | post_p | 0.8 (0.8, 0.8) | 0.5 (0.5, 0.5) | 0.54 (0.54, 0.54) | 0.67 (0.67, 0.67) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | rate | 0.009 (0.009, 0.009) | 0.021 (0.021, 0.021) | 0.01 (0.01, 0.01) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | ||||||||
| TP53+ | TC2 | time | 38 (27, 54) | 38 (27, 54) | 38 (27, 54) | 38 (27, 54) | 38 (27, 54) | 38 (27, 54) | 38 (27, 54) | 38 (27, 54) | ||||||||
| TP53+ | TC2 | n | 30 (20, 39) | 13 (9, 28) | 15 (9, 18) | 10 (6, 18) | 0 (0, 1) | 3 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | post_p | 0.74 (0.71, 0.93) | 0.74 (0.53, 0.83) | 0.89 (0.66, 0.98) | 0.7 (0.57, 0.82) | 0.57 (0.55, 0.6) | 0.53 (0.51, 0.59) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | rate | 0.019 (0.013, 0.022) | 0.019 (0.009, 0.023) | 0.007 (0, 0.011) | 0.012 (0.005, 0.014) | 0 (0, 0) | 0 (0, 0.016) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| TP53+ | TC3 | time | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | ||||||||
| TP53+ | TC3 | n | 17 (17, 17) | 10 (10, 10) | 12 (12, 12) | 9 (9, 9) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC3 | post_p | 0.7 (0.7, 0.7) | 0.72 (0.72, 0.72) | 0.75 (0.75, 0.75) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.55 (0.55, 0.55) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC3 | rate | 0.018 (0.018, 0.018) | 0.007 (0.007, 0.007) | 0.006 (0.006, 0.006) | 0.007 (0.007, 0.007) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | count | 29 | 29 | 29 | 29 | 29 | 29 | 29 | 29 | ||||||||
| TP53+ | TC4 | time | 30 (27, 43) | 30 (27, 43) | 30 (27, 43) | 30 (27, 43) | 30 (27, 43) | 30 (27, 43) | 30 (27, 43) | 30 (27, 43) | ||||||||
| TP53+ | TC4 | n | 22 (14, 32) | 11 (8, 19) | 12 (9, 17) | 9 (6, 16) | 0 (0, 1) | 2 (1, 4) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC4 | post_p | 0.74 (0.72, 0.89) | 0.88 (0.64, 0.97) | 0.73 (0.54, 0.85) | 0.73 (0.6, 0.89) | 0.52 (0.51, 0.53) | 0.53 (0.51, 0.64) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC4 | rate | 0.016 (0.012, 0.025) | 0.005 (0, 0.014) | 0.011 (0.003, 0.018) | 0 (0, 0.011) | 0 (0, 0) | 0 (0, 0.017) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC2 | count | 326 | 326 | 326 | 326 | 326 | 326 | 326 | 326 | ||||||||
| TEfus+ | TC2 | time | 40 (30, 55) | 40 (30, 55) | 40 (30, 55) | 40 (30, 55) | 40 (30, 55) | 40 (30, 55) | 40 (30, 55) | 40 (30, 55) | ||||||||
| TEfus+ | TC2 | n | 5 (2, 9) | 22 (16, 40) | 18 (10, 28) | 14 (8, 27) | 9 (5, 16) | 2 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | post_p | 0.61 (0.52, 0.82) | 0.83 (0.71, 0.97) | 0.86 (0.71, 0.98) | 0.74 (0.57, 0.92) | 0.72 (0.53, 0.9) | 0.54 (0.51, 0.63) | NA (NA, NA) | 0.53 (0.52, 0.55) | ||||||||
| TEfus+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | rate | 0.005 (0, 0.019) | 0.009 (0.003, 0.013) | 0.008 (0, 0.013) | 0.008 (0, 0.015) | 0.007 (0, 0.015) | 0 (0, 0.019) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||
| TEfus+ | TC4 | time | 31 (28, 40) | 31 (28, 40) | 31 (28, 40) | 31 (28, 40) | 31 (28, 40) | 31 (28, 40) | 31 (28, 40) | 31 (28, 40) | ||||||||
| TEfus+ | TC4 | n | 5 (3, 8) | 20 (12, 23) | 11 (9, 16) | 9 (7, 16) | 6 (5, 9) | 2 (2, 4) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | post_p | 0.57 (0.52, 0.65) | 0.83 (0.69, 0.94) | 0.66 (0.52, 0.8) | 0.74 (0.61, 0.86) | 0.54 (0.51, 0.69) | 0.55 (0.54, 0.63) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC4 | rate | 0.006 (0, 0.02) | 0.004 (0, 0.01) | 0.011 (0.007, 0.022) | 0.006 (0, 0.009) | 0.011 (0, 0.019) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | ||||||||
| PI3K+ | TC2 | time | 35 (27, 43) | 35 (27, 43) | 35 (27, 43) | 35 (27, 43) | 35 (27, 43) | 35 (27, 43) | 35 (27, 43) | 35 (27, 43) | ||||||||
| PI3K+ | TC2 | n | 12 (9, 14) | 23 (17, 30) | 13 (9, 23) | 12 (8, 15) | 0 (0, 0) | 2 (1, 4) | 3 (2, 8) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | post_p | 0.77 (0.53, 0.84) | 0.84 (0.8, 0.92) | 0.71 (0.56, 0.79) | 0.71 (0.63, 0.87) | NA (NA, NA) | 0.54 (0.52, 0.57) | 0.53 (0.51, 0.55) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | r_prob | 0.07 (0.07, 0.07) | 0.27 (0.27, 0.27) | 0.27 (0.27, 0.27) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | rate | 0.014 (0.008, 0.024) | 0.005 (0.005, 0.011) | 0.014 (0.01, 0.023) | 0.007 (0.003, 0.011) | NA (NA, NA) | 0 (0, 0.016) | 0.016 (0, 0.027) | NA (NA, NA) | ||||||||
| PI3K+ | TC4 | count | 416 | 416 | 416 | 416 | 416 | 416 | 416 | 416 | ||||||||
| PI3K+ | TC4 | time | 35 (29, 53) | 35 (29, 53) | 35 (29, 53) | 35 (29, 53) | 35 (29, 53) | 35 (29, 53) | 35 (29, 53) | 35 (29, 53) | ||||||||
| PI3K+ | TC4 | n | 14 (8, 22) | 20 (13, 35) | 17 (10, 28) | 12 (7, 22) | 0 (0, 0) | 2 (0, 5) | 3 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC4 | post_p | 0.85 (0.68, 0.98) | 0.82 (0.72, 0.97) | 0.9 (0.72, 0.99) | 0.75 (0.59, 0.93) | NA (NA, NA) | 0.54 (0.51, 0.6) | 0.55 (0.51, 0.67) | 0.53 (0.53, 0.53) | ||||||||
| PI3K+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.31 (0.31, 0.31) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC4 | rate | 0.007 (0, 0.015) | 0.007 (0, 0.012) | 0.007 (0, 0.015) | 0.007 (0, 0.013) | 0 (0, 0) | 0 (0, 0.018) | 0 (0, 0.021) | 0 (0, 0) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 |
| all | TC1 | time | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) | 45 (14, 59) |
| all | TC1 | n | 70 (23, 91) | 13 (8, 22) | 3 (0, 7) | 15 (7, 26) | 20 (7, 35) | 14 (6, 24) | 13 (5, 18) | 8 (4, 13) | 14 (4, 19) | 0 (0, 0) | 8 (4, 14) | 1 (0, 4) | 0 (0, 1) | 2 (0, 4) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.28 (0.08, 0.47) | 0.38 (0.16, 0.49) | 0.44 (0.33, 0.47) | 0.28 (0.03, 0.42) | 0.35 (0.16, 0.46) | 0.24 (0.05, 0.46) | 0.3 (0.08, 0.48) | 0.28 (0.12, 0.44) | 0.41 (0.2, 0.49) | NA (NA, NA) | 0.33 (0.07, 0.47) | 0.4 (0.31, 0.47) | 0.47 (0.41, 0.49) | 0.43 (0.32, 0.49) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.27 (0.27, 0.27) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.028 (0.024, 0.035) | 0.027 (0.019, 0.043) | 0.026 (0.016, 0.098) | 0.025 (0.016, 0.039) | 0.028 (0.022, 0.038) | 0.033 (0.024, 0.052) | 0.027 (0.017, 0.046) | 0.031 (0.019, 0.053) | 0.029 (0.02, 0.04) | NA (NA, NA) | 0.028 (0.018, 0.042) | 0.04 (0, 0.677) | 0.066 (0, 0.541) | 0.035 (0.011, 0.068) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| all | TC2 | time | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) |
| all | TC2 | n | 25 (25, 25) | 7 (7, 7) | 0 (0, 0) | 6 (6, 6) | 9 (9, 9) | 6 (6, 6) | 1 (1, 1) | 3 (3, 3) | 7 (7, 7) | 0 (0, 0) | 6 (6, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.3 (0.3, 0.3) | 0.45 (0.45, 0.45) | NA (NA, NA) | 0.49 (0.49, 0.49) | 0.4 (0.4, 0.4) | 0.41 (0.41, 0.41) | 0.4 (0.4, 0.4) | 0.5 (0.5, 0.5) | 0.32 (0.32, 0.32) | NA (NA, NA) | 0.43 (0.43, 0.43) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.027 (0.027, 0.027) | 0.023 (0.023, 0.023) | NA (NA, NA) | 0 (0, 0) | 0.055 (0.055, 0.055) | 0.029 (0.029, 0.029) | 0.122 (0.122, 0.122) | 0 (0, 0) | 0.066 (0.066, 0.066) | NA (NA, NA) | 0.019 (0.019, 0.019) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| all | TC3 | time | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) |
| all | TC3 | n | 26 (20, 33) | 6 (4, 8) | 0 (0, 1) | 14 (12, 15) | 7 (6, 8) | 5 (3, 7) | 8 (8, 9) | 6 (4, 7) | 4 (3, 5) | 0 (0, 0) | 5 (3, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.33 (0.26, 0.4) | 0.45 (0.42, 0.48) | 0.45 (0.45, 0.45) | 0.37 (0.34, 0.4) | 0.22 (0.1, 0.34) | 0.43 (0.41, 0.44) | 0.41 (0.4, 0.42) | 0.34 (0.27, 0.42) | 0.43 (0.4, 0.45) | NA (NA, NA) | 0.47 (0.45, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.027 (0.024, 0.029) | 0.036 (0.028, 0.045) | 0.31 (0.31, 0.31) | 0.032 (0.029, 0.035) | 0.083 (0.046, 0.121) | 0.053 (0.043, 0.064) | 0.04 (0.037, 0.044) | 0.058 (0.031, 0.085) | 0.036 (0.029, 0.042) | NA (NA, NA) | 0.009 (0.002, 0.016) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| HRD+ | TC1 | count | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | ||||||||
| HRD+ | TC1 | time | 55 (48, 60) | 55 (48, 60) | 55 (48, 60) | 55 (48, 60) | 55 (48, 60) | 55 (48, 60) | 55 (48, 60) | 55 (48, 60) | ||||||||
| HRD+ | TC1 | n | 25 (21, 32) | 0 (0, 0) | 16 (14, 20) | 5 (2, 7) | 0 (0, 2) | 6 (2, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | post_p | 0.2 (0.08, 0.37) | NA (NA, NA) | 0.13 (0.03, 0.44) | 0.43 (0.32, 0.49) | 0.46 (0.45, 0.48) | 0.36 (0.18, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | rate | 0.03 (0.025, 0.043) | NA (NA, NA) | 0.027 (0.02, 0.037) | 0.029 (0.015, 0.059) | 0.057 (0, 0.11) | 0.037 (0.021, 0.054) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC4 | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | ||||||||
| HRD+ | TC4 | time | 57 (54, 59) | 57 (54, 59) | 57 (54, 59) | 57 (54, 59) | 57 (54, 59) | 57 (54, 59) | 57 (54, 59) | 57 (54, 59) | ||||||||
| HRD+ | TC4 | n | 22 (17, 28) | 0 (0, 0) | 22 (18, 25) | 3 (0, 5) | 0 (0, 1) | 4 (1, 7) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC4 | post_p | 0.37 (0.07, 0.44) | NA (NA, NA) | 0.06 (0.02, 0.27) | 0.46 (0.39, 0.49) | 0.45 (0.43, 0.45) | 0.44 (0.28, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| HRD+ | TC4 | rate | 0.028 (0.026, 0.04) | NA (NA, NA) | 0.031 (0.023, 0.038) | 0.018 (0.006, 0.043) | 0.061 (0.057, 0.071) | 0.027 (0.018, 0.053) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | count | 175 | 175 | 175 | 175 | 175 | 175 | 175 | 175 | ||||||||
| TP53+ | TC1 | time | 36 (26, 55) | 36 (26, 55) | 36 (26, 55) | 36 (26, 55) | 36 (26, 55) | 36 (26, 55) | 36 (26, 55) | 36 (26, 55) | ||||||||
| TP53+ | TC1 | n | 23 (16, 40) | 17 (10, 30) | 13 (9, 23) | 10 (6, 17) | 0 (0, 1) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | post_p | 0.36 (0.13, 0.48) | 0.36 (0.11, 0.48) | 0.32 (0.1, 0.48) | 0.31 (0.11, 0.46) | 0.47 (0.44, 0.5) | 0.45 (0.32, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | rate | 0.028 (0.023, 0.037) | 0.028 (0.021, 0.045) | 0.027 (0.017, 0.04) | 0.028 (0.017, 0.043) | 0 (0, 0.097) | 0.033 (0, 0.086) | NA (NA, NA) | 0.032 (0.032, 0.032) | ||||||||
| TP53+ | TC2 | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | ||||||||
| TP53+ | TC2 | time | 28 (23, 40) | 28 (23, 40) | 28 (23, 40) | 28 (23, 40) | 28 (23, 40) | 28 (23, 40) | 28 (23, 40) | 28 (23, 40) | ||||||||
| TP53+ | TC2 | n | 21 (15, 32) | 11 (8, 19) | 12 (9, 22) | 7 (5, 15) | 0 (0, 0) | 2 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | post_p | 0.18 (0.07, 0.35) | 0.4 (0.28, 0.47) | 0.48 (0.42, 0.49) | 0.43 (0.24, 0.48) | NA (NA, NA) | 0.44 (0.33, 0.48) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | rate | 0.032 (0.025, 0.053) | 0.029 (0.017, 0.036) | 0.016 (0.014, 0.021) | 0.021 (0.02, 0.049) | NA (NA, NA) | 0.04 (0.024, 0.096) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | count | 140 | 140 | 140 | 140 | 140 | 140 | 140 | 140 | ||||||||
| TP53+ | TC3 | time | 34 (26, 51) | 34 (26, 51) | 34 (26, 51) | 34 (26, 51) | 34 (26, 51) | 34 (26, 51) | 34 (26, 51) | 34 (26, 51) | ||||||||
| TP53+ | TC3 | n | 24 (16, 36) | 16 (10, 27) | 14 (8, 26) | 11 (6, 22) | 0 (0, 1) | 2 (0, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC3 | post_p | 0.37 (0.14, 0.49) | 0.32 (0.08, 0.47) | 0.29 (0.08, 0.46) | 0.29 (0.06, 0.46) | 0.48 (0.4, 0.49) | 0.48 (0.42, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC3 | rate | 0.029 (0.023, 0.038) | 0.031 (0.02, 0.046) | 0.029 (0.019, 0.042) | 0.029 (0.018, 0.045) | 0 (0, 0.104) | 0.019 (0, 0.059) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| TP53+ | TC4 | time | 30 (28, 32) | 30 (28, 32) | 30 (28, 32) | 30 (28, 32) | 30 (28, 32) | 30 (28, 32) | 30 (28, 32) | 30 (28, 32) | ||||||||
| TP53+ | TC4 | n | 16 (13, 19) | 14 (10, 17) | 11 (11, 11) | 11 (9, 13) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC4 | post_p | 0.36 (0.26, 0.45) | 0.43 (0.41, 0.46) | 0.35 (0.26, 0.45) | 0.45 (0.43, 0.46) | NA (NA, NA) | 0.43 (0.43, 0.43) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC4 | rate | 0.025 (0.02, 0.03) | 0.027 (0.022, 0.032) | 0.026 (0.022, 0.029) | 0.019 (0.018, 0.02) | NA (NA, NA) | 0.054 (0.054, 0.054) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC1 | count | 304 | 304 | 304 | 304 | 304 | 304 | 304 | 304 | ||||||||
| TEfus+ | TC1 | time | 42 (30, 56) | 42 (30, 56) | 42 (30, 56) | 42 (30, 56) | 42 (30, 56) | 42 (30, 56) | 42 (30, 56) | 42 (30, 56) | ||||||||
| TEfus+ | TC1 | n | 5 (2, 9) | 22 (14, 38) | 15 (10, 25) | 12 (7, 21) | 10 (6, 16) | 3 (0, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | post_p | 0.41 (0.23, 0.48) | 0.21 (0.02, 0.45) | 0.32 (0.06, 0.47) | 0.27 (0.07, 0.45) | 0.35 (0.08, 0.48) | 0.44 (0.34, 0.49) | NA (NA, NA) | 0.5 (0.5, 0.5) | ||||||||
| TEfus+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | rate | 0.031 (0.017, 0.061) | 0.025 (0.017, 0.037) | 0.026 (0.018, 0.039) | 0.027 (0.017, 0.046) | 0.026 (0.015, 0.045) | 0.03 (0.005, 0.09) | 0 (0, 0) | 0.039 (0, 0.144) | ||||||||
| TEfus+ | TC3 | count | 51 | 51 | 51 | 51 | 51 | 51 | 51 | 51 | ||||||||
| TEfus+ | TC3 | time | 39 (29, 52) | 39 (29, 52) | 39 (29, 52) | 39 (29, 52) | 39 (29, 52) | 39 (29, 52) | 39 (29, 52) | 39 (29, 52) | ||||||||
| TEfus+ | TC3 | n | 4 (2, 8) | 21 (15, 34) | 14 (10, 24) | 13 (7, 19) | 10 (5, 14) | 2 (0, 4) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC3 | post_p | 0.42 (0.32, 0.49) | 0.13 (0.02, 0.37) | 0.23 (0.04, 0.47) | 0.27 (0.04, 0.41) | 0.45 (0.35, 0.5) | 0.48 (0.42, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC3 | rate | 0.036 (0.02, 0.064) | 0.029 (0.023, 0.042) | 0.03 (0.022, 0.044) | 0.027 (0.02, 0.04) | 0.019 (0.012, 0.028) | 0.015 (0, 0.043) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| TEfus+ | TC4 | time | 32 (27, 45) | 32 (27, 45) | 32 (27, 45) | 32 (27, 45) | 32 (27, 45) | 32 (27, 45) | 32 (27, 45) | 32 (27, 45) | ||||||||
| TEfus+ | TC4 | n | 4 (2, 5) | 20 (14, 26) | 14 (10, 17) | 12 (10, 16) | 9 (7, 10) | 2 (2, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | post_p | 0.38 (0.36, 0.43) | 0.46 (0.45, 0.48) | 0.32 (0.09, 0.36) | 0.45 (0.34, 0.48) | 0.41 (0.33, 0.41) | 0.44 (0.44, 0.48) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC4 | rate | 0.077 (0.049, 0.12) | 0.014 (0.013, 0.016) | 0.025 (0.023, 0.036) | 0.018 (0.017, 0.028) | 0.023 (0.022, 0.066) | 0.058 (0.018, 0.073) | NA (NA, NA) | NA (NA, NA) | ||||||||
| PI3K+ | TC1 | count | 206 | 206 | 206 | 206 | 206 | 206 | 206 | 206 | ||||||||
| PI3K+ | TC1 | time | 39 (27, 55) | 39 (27, 55) | 39 (27, 55) | 39 (27, 55) | 39 (27, 55) | 39 (27, 55) | 39 (27, 55) | 39 (27, 55) | ||||||||
| PI3K+ | TC1 | n | 16 (9, 24) | 20 (13, 35) | 17 (10, 29) | 11 (6, 18) | 0 (0, 0) | 2 (0, 5) | 3 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | post_p | 0.36 (0.13, 0.47) | 0.22 (0.04, 0.43) | 0.34 (0.12, 0.48) | 0.3 (0.09, 0.47) | NA (NA, NA) | 0.44 (0.35, 0.49) | 0.44 (0.34, 0.49) | NA (NA, NA) | ||||||||
| PI3K+ | TC1 | r_prob | 0.27 (0.27, 0.27) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | rate | 0.029 (0.022, 0.042) | 0.025 (0.018, 0.038) | 0.028 (0.021, 0.043) | 0.028 (0.016, 0.044) | NA (NA, NA) | 0.029 (0, 0.088) | 0.032 (0.011, 0.083) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||||||||
| PI3K+ | TC2 | time | 30 (24, 38) | 30 (24, 38) | 30 (24, 38) | 30 (24, 38) | 30 (24, 38) | 30 (24, 38) | 30 (24, 38) | 30 (24, 38) | ||||||||
| PI3K+ | TC2 | n | 11 (8, 17) | 19 (15, 20) | 14 (11, 19) | 8 (5, 9) | 0 (0, 0) | 3 (1, 4) | 3 (1, 4) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | post_p | 0.23 (0.12, 0.38) | 0.45 (0.37, 0.48) | 0.29 (0.23, 0.43) | 0.48 (0.44, 0.5) | NA (NA, NA) | 0.49 (0.47, 0.5) | 0.45 (0.42, 0.49) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | r_prob | 0.07 (0.07, 0.07) | 0.27 (0.27, 0.27) | 0.27 (0.27, 0.27) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | rate | 0.04 (0.035, 0.047) | 0.015 (0.011, 0.019) | 0.03 (0.024, 0.031) | 0.02 (0.019, 0.022) | NA (NA, NA) | 0 (0, 0.031) | 0.046 (0.015, 0.172) | NA (NA, NA) | ||||||||
| PI3K+ | TC3 | count | 101 | 101 | 101 | 101 | 101 | 101 | 101 | 101 | ||||||||
| PI3K+ | TC3 | time | 35 (25, 48) | 35 (25, 48) | 35 (25, 48) | 35 (25, 48) | 35 (25, 48) | 35 (25, 48) | 35 (25, 48) | 35 (25, 48) | ||||||||
| PI3K+ | TC3 | n | 13 (8, 21) | 20 (14, 29) | 16 (11, 25) | 11 (7, 16) | 0 (0, 0) | 2 (0, 4) | 2 (0, 4) | 0 (0, 0) | ||||||||
| PI3K+ | TC3 | post_p | 0.33 (0.14, 0.47) | 0.2 (0.04, 0.41) | 0.3 (0.12, 0.46) | 0.35 (0.07, 0.48) | NA (NA, NA) | 0.47 (0.42, 0.5) | 0.48 (0.42, 0.5) | NA (NA, NA) | ||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC3 | rate | 0.029 (0.022, 0.041) | 0.028 (0.019, 0.037) | 0.03 (0.022, 0.044) | 0.027 (0.016, 0.047) | NA (NA, NA) | 0.019 (0, 0.063) | 0.02 (0, 0.065) | 0 (0, 0) |