Simulation scenario 8, HS phase

Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 6)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.026, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.025, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 35.8, median = 29.3	mean = 32, median = 26.2	mean = 36.8, median = 30.1
all	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.92, hr = 1.12	af = 0.82, hr = 1.29	af = 0.94, hr = 1.08
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.028, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 37.9, median = 31	mean = 78.1, median = 63.8	mean = 32.9, median = 26.9
HRD+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.97, hr = 1.04	af = 2, hr = 0.41	af = 0.84, hr = 1.25
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.025, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.023, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 37.2, median = 30.4	mean = 30.2, median = 24.7	mean = 39.4, median = 32.2
TP53+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.95, hr = 1.07	af = 0.77, hr = 1.4	af = 1.01, hr = 0.99
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.028, shape = 1.3	scale = 0.021, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 72.6, median = 59.3	mean = 32.8, median = 26.8	mean = 43.2, median = 35.3
TEfus+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.86, hr = 0.45	af = 0.84, hr = 1.25	af = 1.11, hr = 0.88
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.023, shape = 1.3	scale = 0.03, shape = 1.3	scale = 0.012, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 40.6, median = 33.2	mean = 30.7, median = 25.1	mean = 78.4, median = 64
PI3K+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.04, hr = 0.95	af = 0.79, hr = 1.36	af = 2.01, hr = 0.4

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 29.4, median = 24
—-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
—+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 78.1, median = 63.8
—+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 2, hr = 0.41
–+-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 78.1, median = 63.8	mean = 29.4, median = 24	mean = 29.4, median = 24
–+-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 2, hr = 0.41	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
–++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 29.4, median = 24	mean = 78.1, median = 63.8
–++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 0.75, hr = 1.44	af = 2, hr = 0.41
-+–	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 29.4, median = 24
-+–	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 78.1, median = 63.8
-+-+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 2, hr = 0.41
-++-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 78.1, median = 63.8	mean = 29.4, median = 24	mean = 29.4, median = 24
-++-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 2, hr = 0.41	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
-+++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 29.4, median = 24	mean = 79.9, median = 65.3
-+++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 0.75, hr = 1.44	af = 2.05, hr = 0.39
+—	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 29.4, median = 24
+—	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 0.75, hr = 1.44
+–+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
+–+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 2, hr = 0.41
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 29.4, median = 24
+-+-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 0.75, hr = 1.44
+-++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
+-++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 2, hr = 0.41
++–	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 29.4, median = 24
++–	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 0.75, hr = 1.44
++-+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
++-+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 2, hr = 0.41
+++-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 29.4, median = 24
+++-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 0.75, hr = 1.44
++++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
++++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 2, hr = 0.41

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 5 17 6 11 HRD+ 0 4 120 0 TP53+ 1 11 1 29 TEfus+ 0 326 0 6 PI3K+ 0 7 0 416

TC1 TC2 TC3 TC4 all 0.010 0.034 0.012 0.022 HRD+ 0.000 0.008 0.240 0.000 TP53+ 0.002 0.022 0.002 0.058 TEfus+ 0.000 0.652 0.000 0.012 PI3K+ 0.000 0.014 0.000 0.832

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 25 1 2 0 HRD+ 19 0 0 11 TP53+ 175 7 140 2 TEfus+ 304 0 51 3 PI3K+ 206 5 101 0

TC1 TC2 TC3 TC4 all 0.050 0.002 0.004 0.000 HRD+ 0.038 0.000 0.000 0.022 TP53+ 0.350 0.014 0.280 0.004 TEfus+ 0.608 0.000 0.102 0.006 PI3K+ 0.412 0.010 0.202 0.000

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.086	0.012	0.046	0.014	0.020
Error subgroup	0.168	0.012	0.072	0.014	0.084
Power signature	0.952	0.000	0.652	0.240	0.832
Power subgroup	0.956	0.000	0.698	0.254	0.852

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	5	17	6	11
all	futility	0	25	1	2	0
all	max_n	0	0	0	0	0
all	n	586 (559, 611)	278 (218, 349)	316 (255, 386)	325 (240, 400)	285 (245, 355)
all	n_unique	586 (559, 611)	278 (218, 349)	316 (255, 386)	325 (240, 400)	285 (245, 355)
all	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)
all	time_stop	NA (NA, NA)	42 (11, 58)	12 (11, 32)	16 (13, 19)	20 (13, 48)
all	post_p	NA (NA, NA)	0.06 (0, 0.39)	0.73 (0.27, 0.97)	0.15 (0.01, 0.55)	0.83 (0.43, 0.98)
all	rate	0.023 (0.022, 0.025)	0.027 (0.025, 0.03)	0.022 (0.02, 0.024)	0.025 (0.023, 0.028)	0.021 (0.019, 0.024)
HRD+	graduation	0	0	4	120	0
HRD+	futility	0	19	0	0	11
HRD+	max_n	0	0	0	0	0
HRD+	n	85 (73, 98)	40 (29, 52)	42 (31, 54)	47 (35, 53)	44 (35, 56)
HRD+	n_unique	85 (73, 98)	40 (29, 52)	42 (31, 54)	47 (35, 53)	44 (35, 56)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (54, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	55 (48, 60)	58 (54, 60)	55 (49, 59)	57 (54, 59)
HRD+	post_p	NA (NA, NA)	0.22 (0.03, 0.64)	0.6 (0.23, 0.9)	1 (0.96, 1)	0.32 (0.04, 0.76)
HRD+	rate	0.023 (0.019, 0.027)	0.027 (0.021, 0.035)	0.021 (0.015, 0.026)	0.009 (0.006, 0.013)	0.025 (0.019, 0.032)
TP53+	graduation	0	1	11	1	29
TP53+	futility	0	175	7	140	2
TP53+	max_n	0	0	0	0	0
TP53+	n	220 (198, 239)	100 (53, 140)	122 (89, 166)	120 (58, 161)	108 (82, 146)
TP53+	n_unique	220 (198, 239)	100 (53, 140)	122 (89, 166)	120 (58, 161)	108 (82, 146)
TP53+	time_trial	60 (60, 60)	60 (29, 60)	60 (60, 60)	60 (32, 60)	60 (60, 60)
TP53+	time_stop	NA (NA, NA)	36 (26, 54)	31 (25, 54)	34 (26, 51)	30 (27, 42)
TP53+	post_p	NA (NA, NA)	0.16 (0.01, 0.57)	0.72 (0.29, 0.96)	0.08 (0, 0.38)	0.83 (0.43, 0.99)
TP53+	rate	0.023 (0.02, 0.025)	0.027 (0.023, 0.033)	0.021 (0.017, 0.024)	0.029 (0.024, 0.034)	0.02 (0.017, 0.023)
TEfus+	graduation	0	0	326	0	6
TEfus+	futility	0	304	0	51	3
TEfus+	max_n	0	0	0	0	0
TEfus+	n	190 (170, 209)	80 (51, 125)	86 (51, 136)	116 (67, 166)	94 (69, 133)
TEfus+	n_unique	190 (170, 209)	80 (51, 125)	86 (51, 136)	116 (67, 166)	94 (69, 133)
TEfus+	time_trial	60 (60, 60)	53 (32, 60)	50 (32, 60)	60 (60, 60)	60 (60, 60)
TEfus+	time_stop	NA (NA, NA)	42 (30, 56)	40 (30, 55)	39 (29, 52)	32 (28, 45)
TEfus+	post_p	NA (NA, NA)	0.01 (0, 0.17)	1 (0.97, 1)	0.03 (0, 0.27)	0.6 (0.17, 0.94)
TEfus+	rate	0.018 (0.016, 0.021)	0.027 (0.023, 0.033)	0.01 (0.008, 0.012)	0.025 (0.021, 0.029)	0.018 (0.014, 0.021)
PI3K+	graduation	0	0	7	0	416
PI3K+	futility	0	206	5	101	0
PI3K+	max_n	0	0	0	0	0
PI3K+	n	205 (185, 223)	94 (53, 138)	117 (78, 166)	126 (60, 175)	72 (51, 127)
PI3K+	n_unique	205 (185, 223)	94 (53, 138)	117 (78, 166)	126 (60, 175)	72 (51, 127)
PI3K+	time_trial	60 (60, 60)	60 (31, 60)	60 (60, 60)	60 (35, 60)	38 (29, 60)
PI3K+	time_stop	NA (NA, NA)	39 (27, 55)	33 (26, 42)	35 (25, 48)	35 (29, 53)
PI3K+	post_p	NA (NA, NA)	0.09 (0, 0.43)	0.8 (0.34, 0.98)	0.05 (0, 0.34)	1 (1, 1)
PI3K+	rate	0.022 (0.019, 0.024)	0.027 (0.023, 0.033)	0.019 (0.016, 0.022)	0.028 (0.023, 0.033)	0.009 (0.007, 0.012)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	5	17	6	11
—-	futility	0	25	1	2	0
—-	max_n	0	0	0	0	0
—-	n	177 (160, 194)	91 (75, 106)	92 (78, 105)	91 (79, 107)	91 (78, 105)
—-	n_unique	177 (160, 194)	91 (75, 106)	92 (78, 105)	91 (79, 107)	91 (78, 105)
—-	post_p	NA (NA, NA)	0.43 (0.08, 0.86)	0.22 (0.02, 0.65)	0.23 (0.02, 0.69)	0.23 (0.03, 0.67)
—-	rate	0.026 (0.023, 0.029)	0.027 (0.023, 0.032)	0.03 (0.025, 0.035)	0.029 (0.025, 0.035)	0.029 (0.025, 0.034)
—+	graduation	0	5	22	6	423
—+	futility	0	213	6	103	0
—+	max_n	0	0	0	0	0
—+	n	42 (34, 50)	22 (11, 32)	26 (17, 37)	24 (13, 33)	15 (8, 25)
—+	n_unique	42 (34, 50)	22 (11, 32)	26 (17, 37)	24 (13, 33)	15 (8, 25)
—+	post_p	NA (NA, NA)	0.41 (0.13, 0.79)	0.3 (0.05, 0.73)	0.29 (0.07, 0.68)	0.98 (0.87, 1)
—+	rate	0.026 (0.02, 0.034)	0.027 (0.019, 0.038)	0.029 (0.021, 0.041)	0.03 (0.021, 0.04)	0.009 (0.004, 0.015)
–+-	graduation	0	5	341	6	17
–+-	futility	0	312	1	53	3
–+-	max_n	0	0	0	0	0
–+-	n	13 (8, 19)	6 (3, 10)	6 (2, 10)	7 (4, 12)	8 (4, 13)
–+-	n_unique	13 (8, 19)	6 (3, 10)	6 (2, 10)	7 (4, 12)	8 (4, 13)
–+-	post_p	NA (NA, NA)	0.37 (0.14, 0.68)	0.73 (0.49, 0.93)	0.35 (0.11, 0.62)	0.35 (0.1, 0.64)
–+-	rate	0.018 (0.009, 0.031)	0.029 (0.012, 0.057)	0.009 (0, 0.023)	0.03 (0.016, 0.057)	0.03 (0.015, 0.053)
–++	graduation	0	5	344	6	424
–++	futility	0	376	3	135	2
–++	max_n	0	0	0	0	0
–++	n	61 (49, 72)	25 (14, 45)	27 (16, 47)	40 (18, 64)	21 (13, 41)
–++	n_unique	61 (49, 72)	25 (14, 45)	27 (16, 47)	40 (18, 64)	21 (13, 41)
–++	post_p	NA (NA, NA)	0.11 (0.01, 0.44)	0.93 (0.66, 0.99)	0.04 (0, 0.29)	0.96 (0.79, 1)
–++	rate	0.018 (0.014, 0.023)	0.027 (0.02, 0.038)	0.01 (0.006, 0.015)	0.03 (0.022, 0.039)	0.009 (0.005, 0.013)
-+–	graduation	0	6	27	6	38
-+–	futility	0	182	8	142	2
-+–	max_n	0	0	0	0	0
-+–	n	76 (65, 87)	36 (18, 48)	42 (30, 56)	37 (20, 49)	41 (29, 54)
-+–	n_unique	76 (65, 87)	36 (18, 48)	42 (30, 56)	37 (20, 49)	41 (29, 54)
-+–	post_p	NA (NA, NA)	0.47 (0.14, 0.85)	0.35 (0.05, 0.78)	0.35 (0.07, 0.74)	0.33 (0.05, 0.74)
-+–	rate	0.026 (0.021, 0.031)	0.028 (0.02, 0.036)	0.029 (0.023, 0.038)	0.03 (0.023, 0.038)	0.03 (0.023, 0.038)
-+-+	graduation	0	5	32	6	426
-+-+	futility	0	274	13	174	2
-+-+	max_n	0	0	0	0	0
-+-+	n	52 (42, 61)	24 (11, 38)	34 (20, 51)	28 (13, 41)	18 (10, 31)
-+-+	n_unique	52 (42, 61)	24 (11, 38)	34 (20, 51)	28 (13, 41)	18 (10, 31)
-+-+	post_p	NA (NA, NA)	0.4 (0.1, 0.84)	0.3 (0.04, 0.74)	0.31 (0.05, 0.73)	0.99 (0.91, 1)
-+-+	rate	0.026 (0.02, 0.032)	0.028 (0.019, 0.04)	0.029 (0.021, 0.039)	0.03 (0.022, 0.041)	0.009 (0.005, 0.015)
-++-	graduation	0	5	344	6	42
-++-	futility	0	370	5	174	5
-++-	max_n	0	0	0	0	0
-++-	n	46 (37, 55)	18 (10, 31)	20 (10, 32)	25 (12, 37)	30 (17, 43)
-++-	n_unique	46 (37, 55)	18 (10, 31)	20 (10, 32)	25 (12, 37)	30 (17, 43)
-++-	post_p	NA (NA, NA)	0.21 (0.03, 0.56)	0.94 (0.76, 1)	0.11 (0.01, 0.43)	0.1 (0.01, 0.45)
-++-	rate	0.018 (0.013, 0.024)	0.028 (0.019, 0.039)	0.009 (0.004, 0.014)	0.03 (0.021, 0.041)	0.03 (0.021, 0.039)
-+++	graduation	0	5	347	6	426
-+++	futility	0	399	7	203	4
-+++	max_n	0	0	0	0	0
-+++	n	35 (25, 44)	13 (7, 28)	17 (7, 33)	21 (8, 40)	14 (7, 26)
-+++	n_unique	35 (25, 44)	13 (7, 28)	17 (7, 33)	21 (8, 40)	14 (7, 26)
-+++	post_p	NA (NA, NA)	0.16 (0.03, 0.53)	0.86 (0.57, 0.98)	0.11 (0.01, 0.38)	0.9 (0.61, 0.98)
-+++	rate	0.018 (0.013, 0.024)	0.028 (0.019, 0.043)	0.01 (0.005, 0.016)	0.03 (0.021, 0.043)	0.009 (0.004, 0.016)
+—	graduation	0	5	21	126	11
+—	futility	0	44	1	2	11
+—	max_n	0	0	0	0	0
+—	n	39 (32, 48)	20 (14, 27)	21 (14, 27)	20 (14, 26)	21 (15, 27)
+—	n_unique	39 (32, 48)	20 (14, 27)	21 (14, 27)	20 (14, 26)	21 (15, 27)
+—	post_p	NA (NA, NA)	0.41 (0.1, 0.81)	0.34 (0.08, 0.71)	0.98 (0.88, 1)	0.33 (0.06, 0.76)
+—	rate	0.026 (0.02, 0.034)	0.027 (0.019, 0.039)	0.029 (0.02, 0.041)	0.009 (0.004, 0.015)	0.029 (0.021, 0.042)
+–+	graduation	0	5	26	125	416
+–+	futility	0	223	6	98	10
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.47 (0.47, 0.47)	NA (NA, NA)
+–+	rate	0 (0, 0)	NA (NA, NA)	0.027 (0.005, 0.112)	0 (0, 0.07)	0.025 (0.005, 0.045)
+-+-	graduation	0	5	343	126	17
+-+-	futility	0	324	1	53	14
+-+-	max_n	0	0	0	0	0
+-+-	n	28 (21, 35)	12 (6, 19)	11 (5, 19)	16 (10, 22)	17 (11, 24)
+-+-	n_unique	28 (21, 35)	12 (6, 19)	11 (5, 19)	16 (10, 22)	17 (11, 24)
+-+-	post_p	NA (NA, NA)	0.22 (0.04, 0.57)	0.78 (0.5, 0.95)	0.85 (0.56, 0.98)	0.17 (0.02, 0.51)
+-+-	rate	0.018 (0.012, 0.025)	0.027 (0.017, 0.043)	0.01 (0.003, 0.018)	0.009 (0.003, 0.017)	0.029 (0.018, 0.042)
+-++	graduation	0	5	346	125	417
+-++	futility	0	382	3	130	12
+-++	max_n	0	0	0	0	0
+-++	n	6 (4, 10)	3 (1, 6)	3 (1, 6)	4 (1, 8)	3 (0, 6)
+-++	n_unique	6 (4, 10)	3 (1, 6)	3 (1, 6)	4 (1, 8)	3 (0, 6)
+-++	post_p	NA (NA, NA)	0.41 (0.24, 0.54)	0.54 (0.42, 0.67)	0.56 (0.44, 0.74)	0.55 (0.43, 0.67)
+-++	rate	0.019 (0.007, 0.041)	0.029 (0.009, 0.081)	0.008 (0, 0.031)	0.007 (0, 0.024)	0.008 (0, 0.03)
++–	graduation	0	6	31	121	38
++–	futility	0	196	8	132	13
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	0 (0, 2)	1 (0, 2)	0 (0, 2)	1 (0, 2)
++–	n_unique	1 (0, 3)	0 (0, 2)	1 (0, 2)	0 (0, 2)	1 (0, 2)
++–	post_p	NA (NA, NA)	0.48 (0.43, 0.55)	0.49 (0.42, 0.57)	0.54 (0.45, 0.59)	0.49 (0.42, 0.57)
++–	rate	0.026 (0, 0.081)	0.029 (0, 0.137)	0.025 (0, 0.123)	0 (0, 0.049)	0.029 (0, 0.124)
++-+	graduation	0	5	36	121	419
++-+	futility	0	282	13	162	12
++-+	max_n	0	0	0	0	0
++-+	n	9 (5, 13)	4 (1, 8)	6 (2, 10)	4 (1, 8)	3 (1, 6)
++-+	n_unique	9 (5, 13)	4 (1, 8)	6 (2, 10)	4 (1, 8)	3 (1, 6)
++-+	post_p	NA (NA, NA)	0.44 (0.25, 0.65)	0.43 (0.21, 0.64)	0.65 (0.44, 0.89)	0.63 (0.45, 0.85)
++-+	rate	0.027 (0.013, 0.044)	0.027 (0.009, 0.069)	0.03 (0.011, 0.06)	0.009 (0, 0.027)	0.009 (0, 0.026)
+++-	graduation	0	5	346	121	42
+++-	futility	0	378	5	164	16
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	0.55 (0.55, 0.55)	0.44 (0.44, 0.44)
+++-	rate	0.014 (0, 0.242)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.018 (0.004, 0.033)
++++	graduation	0	5	349	121	419
++++	futility	0	404	7	191	14
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	0.5 (0.49, 0.51)	0.53 (0.51, 0.55)	0.51 (0.51, 0.51)	0.54 (0.54, 0.54)
++++	rate	0 (0, 0.121)	0.037 (0, 0.109)	0 (0, 0.038)	0 (0, 0)	0 (0, 0.046)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	5	17	6	11
all	time_stop	11 (10, 15)	12 (11, 33)	16 (12, 18)	20 (13, 48)
all	n_trt	57 (52, 71)	64 (53, 161)	83 (62, 100)	108 (67, 238)
all	n_control	110 (103, 131)	112 (93, 307)	143 (110, 168)	193 (120, 462)
all	post_p	0.93 (0.91, 0.97)	0.93 (0.87, 0.99)	0.96 (0.86, 0.98)	0.98 (0.91, 1)
all	order	1 (1, 1)	1 (1, 2)	1 (1, 1)	1 (1, 2)
HRD+	count		4	120
HRD+	time_stop		58 (54, 60)	55 (49, 59)
HRD+	n_trt		54 (51, 60)	51 (50, 54)
HRD+	n_control		77 (73, 84)	78 (64, 96)
HRD+	post_p		0.93 (0.89, 0.97)	1 (0.98, 1)
HRD+	order		2.5 (2, 3)	3 (2, 3)
TP53+	count	1	11	1	29
TP53+	time_stop	24 (24, 24)	38 (27, 54)	33 (33, 33)	30 (27, 43)
TP53+	n_trt	52 (52, 52)	74 (55, 98)	50 (50, 50)	55 (50, 83)
TP53+	n_control	86 (86, 86)	137 (109, 185)	122 (122, 122)	117 (91, 166)
TP53+	post_p	0.88 (0.88, 0.88)	0.97 (0.9, 0.99)	0.96 (0.96, 0.96)	0.98 (0.9, 1)
TP53+	order	1 (1, 1)	2 (1, 3)	1 (1, 1)	1 (1, 2)
TEfus+	count		326		6
TEfus+	time_stop		40 (30, 55)		31 (28, 40)
TEfus+	n_trt		70 (51, 117)		55 (52, 58)
TEfus+	n_control		128 (92, 176)		102 (88, 136)
TEfus+	post_p		0.99 (0.96, 1)		0.99 (0.92, 1)
TEfus+	order		2 (1, 2)		1 (1, 3.5)
PI3K+	count		7		416
PI3K+	time_stop		35 (27, 43)		35 (29, 53)
PI3K+	n_trt		61 (55, 85)		65 (51, 112)
PI3K+	n_control		121 (84, 144)		121 (91, 182)
PI3K+	post_p		0.98 (0.96, 0.99)		1 (0.98, 1)
PI3K+	order		2 (1, 4)		1 (1, 2)

Futility:

signature	var	TC1	TC2	TC3	TC4
all	count	25	1	2
all	time_stop	45 (14, 59)	12 (12, 12)	17 (15, 19)
all	n_trt	197 (75, 244)	70 (70, 70)	81 (79, 83)
all	n_control	453 (125, 575)	105 (105, 105)	148 (120, 176)
all	post_p	0.01 (0, 0.04)	0.04 (0.04, 0.04)	0.02 (0.01, 0.03)
all	order	3 (1, 5)	1 (1, 1)	1 (1, 1)
HRD+	count	19			11
HRD+	time_stop	55 (48, 60)			57 (54, 59)
HRD+	n_trt	50 (50, 57)			51 (50, 53)
HRD+	n_control	72 (62, 90)			84 (76, 91)
HRD+	post_p	0.04 (0.01, 0.16)			0.06 (0.01, 0.09)
HRD+	order	2 (1, 4)			3 (2, 6)
TP53+	count	175	7	140	2
TP53+	time_stop	36 (26, 55)	28 (23, 40)	34 (26, 51)	30 (28, 32)
TP53+	n_trt	67 (51, 110)	50 (50, 85)	68 (51, 111)	52 (51, 54)
TP53+	n_control	129 (91, 204)	101 (81, 144)	124 (88, 194)	112 (104, 121)
TP53+	post_p	0.09 (0.02, 0.2)	0.11 (0.05, 0.23)	0.07 (0.01, 0.18)	0.15 (0.13, 0.17)
TP53+	order	2 (1, 3)	1 (1, 2.2)	2 (1, 3)	1 (1, 1)
TEfus+	count	304		51	3
TEfus+	time_stop	42 (30, 56)		39 (29, 52)	32 (27, 45)
TEfus+	n_trt	66 (51, 105)		66 (50, 97)	54 (53, 74)
TEfus+	n_control	131 (92, 177)		127 (92, 161)	115 (101, 138)
TEfus+	post_p	0.03 (0, 0.13)		0.02 (0, 0.14)	0.07 (0.06, 0.07)
TEfus+	order	2 (1, 3)		2 (1, 4)	1 (1, 1.8)
PI3K+	count	206	5	101
PI3K+	time_stop	39 (27, 55)	30 (24, 38)	35 (25, 48)
PI3K+	n_trt	68 (51, 106)	53 (52, 65)	62 (51, 95)
PI3K+	n_control	130 (87, 188)	95 (86, 124)	116 (85, 165)
PI3K+	post_p	0.05 (0.01, 0.18)	0.17 (0.08, 0.18)	0.05 (0.01, 0.17)
PI3K+	order	2 (1, 3.5)	2 (1, 2)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC1	time	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)	11 (10, 15)
all	TC1	n	20 (17, 27)	6 (3, 7)	2 (0, 3)	8 (3, 10)	6 (3, 9)	4 (4, 6)	3 (1, 4)	3 (1, 6)	4 (3, 5)	0 (0, 0)	2 (1, 3)	1 (0, 3)	0 (0, 1)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.74 (0.58, 0.76)	0.54 (0.5, 0.67)	0.53 (0.52, 0.55)	0.52 (0.51, 0.56)	0.55 (0.51, 0.57)	0.53 (0.52, 0.55)	0.54 (0.52, 0.57)	0.53 (0.51, 0.54)	0.52 (0.51, 0.53)	NA (NA, NA)	0.54 (0.53, 0.55)	0.53 (0.52, 0.53)	NA (NA, NA)	0.53 (0.51, 0.54)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.008 (0.002, 0.013)	0 (0, 0)	0 (0, 0)	0 (0, 0.014)	0 (0, 0.007)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0.036)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17
all	TC2	time	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)	12 (11, 33)
all	TC2	n	23 (15, 49)	5 (2, 11)	2 (0, 6)	10 (6, 16)	9 (4, 23)	6 (3, 11)	5 (3, 13)	6 (3, 9)	4 (2, 9)	0 (0, 0)	3 (1, 7)	0 (0, 2)	0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.61 (0.55, 0.72)	0.54 (0.51, 0.59)	0.52 (0.5, 0.59)	0.6 (0.52, 0.85)	0.57 (0.51, 0.74)	0.53 (0.5, 0.75)	0.57 (0.52, 0.82)	0.55 (0.51, 0.78)	0.52 (0.51, 0.57)	NA (NA, NA)	0.54 (0.51, 0.64)	0.52 (0.51, 0.52)	NA (NA, NA)	0.51 (0.5, 0.55)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.014 (0, 0.024)	0 (0, 0.018)	0 (0, 0.013)	0 (0, 0.009)	0.012 (0, 0.021)	0 (0, 0.036)	0 (0, 0.006)	0 (0, 0.008)	0 (0, 0.021)	NA (NA, NA)	0 (0, 0.004)	0 (0, 0.005)	0 (0, 0)	0 (0, 0.037)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
all	TC3	time	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)	16 (12, 18)
all	TC3	n	28 (18, 32)	5 (2, 10)	2 (0, 4)	8 (5, 11)	8 (6, 20)	7 (2, 10)	6 (2, 9)	5 (3, 8)	5 (4, 6)	0 (0, 0)	4 (2, 7)	0 (0, 1)	0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.64 (0.54, 0.89)	0.55 (0.52, 0.58)	0.54 (0.51, 0.58)	0.53 (0.51, 0.6)	0.55 (0.52, 0.75)	0.52 (0.51, 0.54)	0.52 (0.51, 0.55)	0.54 (0.52, 0.58)	0.53 (0.52, 0.56)	NA (NA, NA)	0.57 (0.53, 0.6)	0.55 (0.54, 0.56)	NA (NA, NA)	0.53 (0.52, 0.54)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.011 (0.002, 0.021)	0 (0, 0.006)	0 (0, 0.043)	0.005 (0, 0.022)	0.008 (0, 0.018)	0.006 (0, 0.017)	0 (0, 0.016)	0 (0, 0)	0 (0, 0.006)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11
all	TC4	time	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)	20 (13, 48)
all	TC4	n	36 (20, 63)	8 (5, 16)	2 (0, 5)	12 (7, 20)	14 (8, 25)	9 (4, 13)	6 (4, 14)	7 (2, 18)	9 (2, 12)	0 (0, 0)	4 (2, 12)	0 (0, 4)	0 (0, 1)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.63 (0.55, 0.7)	0.62 (0.51, 0.98)	0.54 (0.52, 0.55)	0.62 (0.5, 0.79)	0.62 (0.52, 0.8)	0.62 (0.54, 0.95)	0.54 (0.52, 0.7)	0.6 (0.54, 0.7)	0.57 (0.5, 0.65)	NA (NA, NA)	0.55 (0.53, 0.62)	0.53 (0.51, 0.59)	0.52 (0.51, 0.53)	0.54 (0.51, 0.57)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.018 (0.009, 0.024)	0.005 (0, 0.016)	0 (0, 0.013)	0 (0, 0.01)	0.017 (0, 0.024)	0.007 (0, 0.013)	0 (0, 0.019)	0 (0, 0.015)	0 (0, 0.025)	0 (0, 0)	0 (0, 0.013)	0 (0, 0.021)	0 (0, 0)	0 (0, 0.004)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									4	4	4	4	4	4	4	4
HRD+	TC2	time									58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)
HRD+	TC2	n									24 (22, 29)	0 (0, 0)	18 (16, 21)	4 (3, 5)	0 (0, 1)	9 (3, 10)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.84 (0.81, 0.91)	NA (NA, NA)	0.79 (0.73, 0.85)	0.62 (0.54, 0.63)	0.52 (0.52, 0.52)	0.62 (0.57, 0.65)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.018 (0.013, 0.021)	NA (NA, NA)	0.009 (0.007, 0.011)	0.006 (0, 0.019)	0 (0, 0)	0.022 (0.006, 0.023)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									120	120	120	120	120	120	120	120
HRD+	TC3	time									55 (49, 59)	55 (49, 59)	55 (49, 59)	55 (49, 59)	55 (49, 59)	55 (49, 59)	55 (49, 59)	55 (49, 59)
HRD+	TC3	n									21 (17, 27)	0 (0, 0)	18 (14, 23)	5 (2, 9)	0 (0, 2)	5 (3, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.98 (0.81, 1)	NA (NA, NA)	0.9 (0.74, 0.97)	0.58 (0.52, 0.7)	0.54 (0.52, 0.6)	0.68 (0.53, 0.91)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.009 (0.005, 0.014)	0 (0, 0.08)	0.007 (0.002, 0.013)	0 (0, 0.016)	0 (0, 0.02)	0.006 (0, 0.016)	0 (0, 0)	0 (0, 0)
TP53+	TC1	count					1	1	1	1					1	1	1	1
TP53+	TC1	time					24 (24, 24)	24 (24, 24)	24 (24, 24)	24 (24, 24)					24 (24, 24)	24 (24, 24)	24 (24, 24)	24 (24, 24)
TP53+	TC1	n					27 (27, 27)	10 (10, 10)	7 (7, 7)	5 (5, 5)					0 (0, 0)	3 (3, 3)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.8 (0.8, 0.8)	0.5 (0.5, 0.5)	0.54 (0.54, 0.54)	0.67 (0.67, 0.67)					NA (NA, NA)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.009 (0.009, 0.009)	0.021 (0.021, 0.021)	0.01 (0.01, 0.01)	0 (0, 0)					NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					11	11	11	11					11	11	11	11
TP53+	TC2	time					38 (27, 54)	38 (27, 54)	38 (27, 54)	38 (27, 54)					38 (27, 54)	38 (27, 54)	38 (27, 54)	38 (27, 54)
TP53+	TC2	n					30 (20, 39)	13 (9, 28)	15 (9, 18)	10 (6, 18)					0 (0, 1)	3 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.74 (0.71, 0.93)	0.74 (0.53, 0.83)	0.89 (0.66, 0.98)	0.7 (0.57, 0.82)					0.57 (0.55, 0.6)	0.53 (0.51, 0.59)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.019 (0.013, 0.022)	0.019 (0.009, 0.023)	0.007 (0, 0.011)	0.012 (0.005, 0.014)					0 (0, 0)	0 (0, 0.016)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					1	1	1	1					1	1	1	1
TP53+	TC3	time					33 (33, 33)	33 (33, 33)	33 (33, 33)	33 (33, 33)					33 (33, 33)	33 (33, 33)	33 (33, 33)	33 (33, 33)
TP53+	TC3	n					17 (17, 17)	10 (10, 10)	12 (12, 12)	9 (9, 9)					0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.7 (0.7, 0.7)	0.72 (0.72, 0.72)	0.75 (0.75, 0.75)	0.5 (0.5, 0.5)					NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.018 (0.018, 0.018)	0.007 (0.007, 0.007)	0.006 (0.006, 0.006)	0.007 (0.007, 0.007)					NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					29	29	29	29					29	29	29	29
TP53+	TC4	time					30 (27, 43)	30 (27, 43)	30 (27, 43)	30 (27, 43)					30 (27, 43)	30 (27, 43)	30 (27, 43)	30 (27, 43)
TP53+	TC4	n					22 (14, 32)	11 (8, 19)	12 (9, 17)	9 (6, 16)					0 (0, 1)	2 (1, 4)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.74 (0.72, 0.89)	0.88 (0.64, 0.97)	0.73 (0.54, 0.85)	0.73 (0.6, 0.89)					0.52 (0.51, 0.53)	0.53 (0.51, 0.64)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.016 (0.012, 0.025)	0.005 (0, 0.014)	0.011 (0.003, 0.018)	0 (0, 0.011)					0 (0, 0)	0 (0, 0.017)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			326	326			326	326			326	326			326	326
TEfus+	TC2	time			40 (30, 55)	40 (30, 55)			40 (30, 55)	40 (30, 55)			40 (30, 55)	40 (30, 55)			40 (30, 55)	40 (30, 55)
TEfus+	TC2	n			5 (2, 9)	22 (16, 40)			18 (10, 28)	14 (8, 27)			9 (5, 16)	2 (1, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.61 (0.52, 0.82)	0.83 (0.71, 0.97)			0.86 (0.71, 0.98)	0.74 (0.57, 0.92)			0.72 (0.53, 0.9)	0.54 (0.51, 0.63)			NA (NA, NA)	0.53 (0.52, 0.55)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.005 (0, 0.019)	0.009 (0.003, 0.013)			0.008 (0, 0.013)	0.008 (0, 0.015)			0.007 (0, 0.015)	0 (0, 0.019)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	count			6	6			6	6			6	6			6	6
TEfus+	TC4	time			31 (28, 40)	31 (28, 40)			31 (28, 40)	31 (28, 40)			31 (28, 40)	31 (28, 40)			31 (28, 40)	31 (28, 40)
TEfus+	TC4	n			5 (3, 8)	20 (12, 23)			11 (9, 16)	9 (7, 16)			6 (5, 9)	2 (2, 4)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.57 (0.52, 0.65)	0.83 (0.69, 0.94)			0.66 (0.52, 0.8)	0.74 (0.61, 0.86)			0.54 (0.51, 0.69)	0.55 (0.54, 0.63)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.006 (0, 0.02)	0.004 (0, 0.01)			0.011 (0.007, 0.022)	0.006 (0, 0.009)			0.011 (0, 0.019)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC2	count		7		7		7		7		7		7		7		7
PI3K+	TC2	time		35 (27, 43)		35 (27, 43)		35 (27, 43)		35 (27, 43)		35 (27, 43)		35 (27, 43)		35 (27, 43)		35 (27, 43)
PI3K+	TC2	n		12 (9, 14)		23 (17, 30)		13 (9, 23)		12 (8, 15)		0 (0, 0)		2 (1, 4)		3 (2, 8)		0 (0, 0)
PI3K+	TC2	post_p		0.77 (0.53, 0.84)		0.84 (0.8, 0.92)		0.71 (0.56, 0.79)		0.71 (0.63, 0.87)		NA (NA, NA)		0.54 (0.52, 0.57)		0.53 (0.51, 0.55)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.014 (0.008, 0.024)		0.005 (0.005, 0.011)		0.014 (0.01, 0.023)		0.007 (0.003, 0.011)		NA (NA, NA)		0 (0, 0.016)		0.016 (0, 0.027)		NA (NA, NA)
PI3K+	TC4	count		416		416		416		416		416		416		416		416
PI3K+	TC4	time		35 (29, 53)		35 (29, 53)		35 (29, 53)		35 (29, 53)		35 (29, 53)		35 (29, 53)		35 (29, 53)		35 (29, 53)
PI3K+	TC4	n		14 (8, 22)		20 (13, 35)		17 (10, 28)		12 (7, 22)		0 (0, 0)		2 (0, 5)		3 (1, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.85 (0.68, 0.98)		0.82 (0.72, 0.97)		0.9 (0.72, 0.99)		0.75 (0.59, 0.93)		NA (NA, NA)		0.54 (0.51, 0.6)		0.55 (0.51, 0.67)		0.53 (0.53, 0.53)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.007 (0, 0.015)		0.007 (0, 0.012)		0.007 (0, 0.015)		0.007 (0, 0.013)		0 (0, 0)		0 (0, 0.018)		0 (0, 0.021)		0 (0, 0)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	25	25	25	25	25	25	25	25	25	25	25	25	25	25	25	25
all	TC1	time	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)	45 (14, 59)
all	TC1	n	70 (23, 91)	13 (8, 22)	3 (0, 7)	15 (7, 26)	20 (7, 35)	14 (6, 24)	13 (5, 18)	8 (4, 13)	14 (4, 19)	0 (0, 0)	8 (4, 14)	1 (0, 4)	0 (0, 1)	2 (0, 4)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.28 (0.08, 0.47)	0.38 (0.16, 0.49)	0.44 (0.33, 0.47)	0.28 (0.03, 0.42)	0.35 (0.16, 0.46)	0.24 (0.05, 0.46)	0.3 (0.08, 0.48)	0.28 (0.12, 0.44)	0.41 (0.2, 0.49)	NA (NA, NA)	0.33 (0.07, 0.47)	0.4 (0.31, 0.47)	0.47 (0.41, 0.49)	0.43 (0.32, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.028 (0.024, 0.035)	0.027 (0.019, 0.043)	0.026 (0.016, 0.098)	0.025 (0.016, 0.039)	0.028 (0.022, 0.038)	0.033 (0.024, 0.052)	0.027 (0.017, 0.046)	0.031 (0.019, 0.053)	0.029 (0.02, 0.04)	NA (NA, NA)	0.028 (0.018, 0.042)	0.04 (0, 0.677)	0.066 (0, 0.541)	0.035 (0.011, 0.068)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC2	time	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)
all	TC2	n	25 (25, 25)	7 (7, 7)	0 (0, 0)	6 (6, 6)	9 (9, 9)	6 (6, 6)	1 (1, 1)	3 (3, 3)	7 (7, 7)	0 (0, 0)	6 (6, 6)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.3 (0.3, 0.3)	0.45 (0.45, 0.45)	NA (NA, NA)	0.49 (0.49, 0.49)	0.4 (0.4, 0.4)	0.41 (0.41, 0.41)	0.4 (0.4, 0.4)	0.5 (0.5, 0.5)	0.32 (0.32, 0.32)	NA (NA, NA)	0.43 (0.43, 0.43)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.027 (0.027, 0.027)	0.023 (0.023, 0.023)	NA (NA, NA)	0 (0, 0)	0.055 (0.055, 0.055)	0.029 (0.029, 0.029)	0.122 (0.122, 0.122)	0 (0, 0)	0.066 (0.066, 0.066)	NA (NA, NA)	0.019 (0.019, 0.019)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC3	time	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)
all	TC3	n	26 (20, 33)	6 (4, 8)	0 (0, 1)	14 (12, 15)	7 (6, 8)	5 (3, 7)	8 (8, 9)	6 (4, 7)	4 (3, 5)	0 (0, 0)	5 (3, 7)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.33 (0.26, 0.4)	0.45 (0.42, 0.48)	0.45 (0.45, 0.45)	0.37 (0.34, 0.4)	0.22 (0.1, 0.34)	0.43 (0.41, 0.44)	0.41 (0.4, 0.42)	0.34 (0.27, 0.42)	0.43 (0.4, 0.45)	NA (NA, NA)	0.47 (0.45, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.027 (0.024, 0.029)	0.036 (0.028, 0.045)	0.31 (0.31, 0.31)	0.032 (0.029, 0.035)	0.083 (0.046, 0.121)	0.053 (0.043, 0.064)	0.04 (0.037, 0.044)	0.058 (0.031, 0.085)	0.036 (0.029, 0.042)	NA (NA, NA)	0.009 (0.002, 0.016)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									19	19	19	19	19	19	19	19
HRD+	TC1	time									55 (48, 60)	55 (48, 60)	55 (48, 60)	55 (48, 60)	55 (48, 60)	55 (48, 60)	55 (48, 60)	55 (48, 60)
HRD+	TC1	n									25 (21, 32)	0 (0, 0)	16 (14, 20)	5 (2, 7)	0 (0, 2)	6 (2, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.2 (0.08, 0.37)	NA (NA, NA)	0.13 (0.03, 0.44)	0.43 (0.32, 0.49)	0.46 (0.45, 0.48)	0.36 (0.18, 0.49)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.03 (0.025, 0.043)	NA (NA, NA)	0.027 (0.02, 0.037)	0.029 (0.015, 0.059)	0.057 (0, 0.11)	0.037 (0.021, 0.054)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									11	11	11	11	11	11	11	11
HRD+	TC4	time									57 (54, 59)	57 (54, 59)	57 (54, 59)	57 (54, 59)	57 (54, 59)	57 (54, 59)	57 (54, 59)	57 (54, 59)
HRD+	TC4	n									22 (17, 28)	0 (0, 0)	22 (18, 25)	3 (0, 5)	0 (0, 1)	4 (1, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.37 (0.07, 0.44)	NA (NA, NA)	0.06 (0.02, 0.27)	0.46 (0.39, 0.49)	0.45 (0.43, 0.45)	0.44 (0.28, 0.49)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.028 (0.026, 0.04)	NA (NA, NA)	0.031 (0.023, 0.038)	0.018 (0.006, 0.043)	0.061 (0.057, 0.071)	0.027 (0.018, 0.053)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					175	175	175	175					175	175	175	175
TP53+	TC1	time					36 (26, 55)	36 (26, 55)	36 (26, 55)	36 (26, 55)					36 (26, 55)	36 (26, 55)	36 (26, 55)	36 (26, 55)
TP53+	TC1	n					23 (16, 40)	17 (10, 30)	13 (9, 23)	10 (6, 17)					0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.36 (0.13, 0.48)	0.36 (0.11, 0.48)	0.32 (0.1, 0.48)	0.31 (0.11, 0.46)					0.47 (0.44, 0.5)	0.45 (0.32, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.028 (0.023, 0.037)	0.028 (0.021, 0.045)	0.027 (0.017, 0.04)	0.028 (0.017, 0.043)					0 (0, 0.097)	0.033 (0, 0.086)	NA (NA, NA)	0.032 (0.032, 0.032)
TP53+	TC2	count					7	7	7	7					7	7	7	7
TP53+	TC2	time					28 (23, 40)	28 (23, 40)	28 (23, 40)	28 (23, 40)					28 (23, 40)	28 (23, 40)	28 (23, 40)	28 (23, 40)
TP53+	TC2	n					21 (15, 32)	11 (8, 19)	12 (9, 22)	7 (5, 15)					0 (0, 0)	2 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.18 (0.07, 0.35)	0.4 (0.28, 0.47)	0.48 (0.42, 0.49)	0.43 (0.24, 0.48)					NA (NA, NA)	0.44 (0.33, 0.48)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.032 (0.025, 0.053)	0.029 (0.017, 0.036)	0.016 (0.014, 0.021)	0.021 (0.02, 0.049)					NA (NA, NA)	0.04 (0.024, 0.096)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					140	140	140	140					140	140	140	140
TP53+	TC3	time					34 (26, 51)	34 (26, 51)	34 (26, 51)	34 (26, 51)					34 (26, 51)	34 (26, 51)	34 (26, 51)	34 (26, 51)
TP53+	TC3	n					24 (16, 36)	16 (10, 27)	14 (8, 26)	11 (6, 22)					0 (0, 1)	2 (0, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.37 (0.14, 0.49)	0.32 (0.08, 0.47)	0.29 (0.08, 0.46)	0.29 (0.06, 0.46)					0.48 (0.4, 0.49)	0.48 (0.42, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.029 (0.023, 0.038)	0.031 (0.02, 0.046)	0.029 (0.019, 0.042)	0.029 (0.018, 0.045)					0 (0, 0.104)	0.019 (0, 0.059)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					2	2	2	2					2	2	2	2
TP53+	TC4	time					30 (28, 32)	30 (28, 32)	30 (28, 32)	30 (28, 32)					30 (28, 32)	30 (28, 32)	30 (28, 32)	30 (28, 32)
TP53+	TC4	n					16 (13, 19)	14 (10, 17)	11 (11, 11)	11 (9, 13)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.36 (0.26, 0.45)	0.43 (0.41, 0.46)	0.35 (0.26, 0.45)	0.45 (0.43, 0.46)					NA (NA, NA)	0.43 (0.43, 0.43)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.025 (0.02, 0.03)	0.027 (0.022, 0.032)	0.026 (0.022, 0.029)	0.019 (0.018, 0.02)					NA (NA, NA)	0.054 (0.054, 0.054)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			304	304			304	304			304	304			304	304
TEfus+	TC1	time			42 (30, 56)	42 (30, 56)			42 (30, 56)	42 (30, 56)			42 (30, 56)	42 (30, 56)			42 (30, 56)	42 (30, 56)
TEfus+	TC1	n			5 (2, 9)	22 (14, 38)			15 (10, 25)	12 (7, 21)			10 (6, 16)	3 (0, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.41 (0.23, 0.48)	0.21 (0.02, 0.45)			0.32 (0.06, 0.47)	0.27 (0.07, 0.45)			0.35 (0.08, 0.48)	0.44 (0.34, 0.49)			NA (NA, NA)	0.5 (0.5, 0.5)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.031 (0.017, 0.061)	0.025 (0.017, 0.037)			0.026 (0.018, 0.039)	0.027 (0.017, 0.046)			0.026 (0.015, 0.045)	0.03 (0.005, 0.09)			0 (0, 0)	0.039 (0, 0.144)
TEfus+	TC3	count			51	51			51	51			51	51			51	51
TEfus+	TC3	time			39 (29, 52)	39 (29, 52)			39 (29, 52)	39 (29, 52)			39 (29, 52)	39 (29, 52)			39 (29, 52)	39 (29, 52)
TEfus+	TC3	n			4 (2, 8)	21 (15, 34)			14 (10, 24)	13 (7, 19)			10 (5, 14)	2 (0, 4)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.42 (0.32, 0.49)	0.13 (0.02, 0.37)			0.23 (0.04, 0.47)	0.27 (0.04, 0.41)			0.45 (0.35, 0.5)	0.48 (0.42, 0.5)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.036 (0.02, 0.064)	0.029 (0.023, 0.042)			0.03 (0.022, 0.044)	0.027 (0.02, 0.04)			0.019 (0.012, 0.028)	0.015 (0, 0.043)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			3	3			3	3			3	3			3	3
TEfus+	TC4	time			32 (27, 45)	32 (27, 45)			32 (27, 45)	32 (27, 45)			32 (27, 45)	32 (27, 45)			32 (27, 45)	32 (27, 45)
TEfus+	TC4	n			4 (2, 5)	20 (14, 26)			14 (10, 17)	12 (10, 16)			9 (7, 10)	2 (2, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.38 (0.36, 0.43)	0.46 (0.45, 0.48)			0.32 (0.09, 0.36)	0.45 (0.34, 0.48)			0.41 (0.33, 0.41)	0.44 (0.44, 0.48)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.077 (0.049, 0.12)	0.014 (0.013, 0.016)			0.025 (0.023, 0.036)	0.018 (0.017, 0.028)			0.023 (0.022, 0.066)	0.058 (0.018, 0.073)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		206		206		206		206		206		206		206		206
PI3K+	TC1	time		39 (27, 55)		39 (27, 55)		39 (27, 55)		39 (27, 55)		39 (27, 55)		39 (27, 55)		39 (27, 55)		39 (27, 55)
PI3K+	TC1	n		16 (9, 24)		20 (13, 35)		17 (10, 29)		11 (6, 18)		0 (0, 0)		2 (0, 5)		3 (1, 6)		0 (0, 0)
PI3K+	TC1	post_p		0.36 (0.13, 0.47)		0.22 (0.04, 0.43)		0.34 (0.12, 0.48)		0.3 (0.09, 0.47)		NA (NA, NA)		0.44 (0.35, 0.49)		0.44 (0.34, 0.49)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.029 (0.022, 0.042)		0.025 (0.018, 0.038)		0.028 (0.021, 0.043)		0.028 (0.016, 0.044)		NA (NA, NA)		0.029 (0, 0.088)		0.032 (0.011, 0.083)		0 (0, 0)
PI3K+	TC2	count		5		5		5		5		5		5		5		5
PI3K+	TC2	time		30 (24, 38)		30 (24, 38)		30 (24, 38)		30 (24, 38)		30 (24, 38)		30 (24, 38)		30 (24, 38)		30 (24, 38)
PI3K+	TC2	n		11 (8, 17)		19 (15, 20)		14 (11, 19)		8 (5, 9)		0 (0, 0)		3 (1, 4)		3 (1, 4)		0 (0, 0)
PI3K+	TC2	post_p		0.23 (0.12, 0.38)		0.45 (0.37, 0.48)		0.29 (0.23, 0.43)		0.48 (0.44, 0.5)		NA (NA, NA)		0.49 (0.47, 0.5)		0.45 (0.42, 0.49)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.04 (0.035, 0.047)		0.015 (0.011, 0.019)		0.03 (0.024, 0.031)		0.02 (0.019, 0.022)		NA (NA, NA)		0 (0, 0.031)		0.046 (0.015, 0.172)		NA (NA, NA)
PI3K+	TC3	count		101		101		101		101		101		101		101		101
PI3K+	TC3	time		35 (25, 48)		35 (25, 48)		35 (25, 48)		35 (25, 48)		35 (25, 48)		35 (25, 48)		35 (25, 48)		35 (25, 48)
PI3K+	TC3	n		13 (8, 21)		20 (14, 29)		16 (11, 25)		11 (7, 16)		0 (0, 0)		2 (0, 4)		2 (0, 4)		0 (0, 0)
PI3K+	TC3	post_p		0.33 (0.14, 0.47)		0.2 (0.04, 0.41)		0.3 (0.12, 0.46)		0.35 (0.07, 0.48)		NA (NA, NA)		0.47 (0.42, 0.5)		0.48 (0.42, 0.5)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.029 (0.022, 0.041)		0.028 (0.019, 0.037)		0.03 (0.022, 0.044)		0.027 (0.016, 0.047)		NA (NA, NA)		0.019 (0, 0.063)		0.02 (0, 0.065)		0 (0, 0)